Impact of body mass index on 5-year survival rates in patients undergoing allogeneic hematopoietic stem cell transplantation

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Abstract Background The association between cancer survival and body mass index (BMI) has been elucidated. However, the impact of patients’ baseline characteristics on allogeneic hematopoietic stem cell transplantation (allo-HSCT) outcomes remains unclear. Objectives To examine the baseline clinical factors associated with 5-year survival rates in patients undergoing allo-HSCT. Study design This was a retrospective exploratory observational study. Patients (n=113, average age: 55 years; 52 women) who underwent allo-HSCT at the Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, between January 2008 and March 2015 were included in this study. Results The 5-year survival rate (65%) was associated with the baseline geriatric nutritional risk index (GNRI; odds ratio [OR]=1.20, 95% confidence interval [CI]: 1.03–1.36, P <0.01) and the BMI (OR=1.06, 95% CI: 1.02–1.12, P <0.01). The cut-off values for BMI and GNRI were 20.5 kg/m 2 and 101 points, respectively (area under the curve, 0.65017 and 0.67637, respectively). The 5-year survival rate was poorer for patients with sarcopenia (41.5%) than for those without sarcopenia prior to allo-HSCT (p=0.05). Conclusions BMI and GNRI values before allo-HCST pre-treatment were independent predictors of the 5-year survival rates. Patients undergoing allo-HSCT may require nutritional interventions during pre-treatment to reduce the risk of sarcopenia, which affects their survival rates.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.