Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF‐κB , JAK / STAT , and MAPK signaling pathways
Rattachement africain : ir. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Three main inflammatory signaling pathways include nuclear factor-κB (NF-κB), Janus kinases/Signal transducer and activator of transcriptions (JAKs/STATs), and mitogen-activated protein kinases (MAPKs) play crucial roles in inducing, promoting, and regulating inflammatory responses in the immune system. Importantly, the breakdown of mechanisms that tightly regulate inflammatory signaling pathways can be the underlying cause of uncontrolled inflammatory responses and be associated with the generation and development of several inflammatory diseases. Hence, therapeutic strategies targeting inflammatory signaling pathways and their downstream components may promise to treat inflammatory diseases. Studies over the past two decades have provided important information on the polytrophic pharmacological and biochemical properties of berberine (BBR) as a naturally occurring compound, such as antioxidant, antitumor, antimicrobial, and antiinflammatory activates. Interestingly, the modulatory effects of BBR on inflammatory signaling cascades, which lead to the inhibition of inflammation, have been widely investigated in several in vitro and in vivo studies. For the first time, herein, this comprehensive review attempts to put together these studies and provide important insight into the modulatory effects of BBR on NF-κB, JAKs/STATs, and MAPKs signaling pathways in vitro in various types of immune cells and in vivo in several experimental inflammatory diseases. As the second achievement of this review, we also explore the therapeutic efficacy and antiinflammatory effects of BBR regarding its modulatory action.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on <scp>NF‐κB</scp> , <scp>JAK</scp> / <scp>STAT</scp> , and <scp>MAPK</scp> signaling pathways
- Date Crossref
- 10/02/2022
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Neyshabur pays non établi dans la noticeUniversité ou école supérieure
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Neyshabur University of Medical Sciences Department of Basic Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Pasteur Institute of Iran Center for Reference and Research on Rabies pays non établi dans la noticeStructure de recherche
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Rafsanjan University of Medical Sciences Immunology of Infectious Diseases Research Center pays non établi dans la noticeUniversité ou école supérieure
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Bushehr University of Medical Sciences Department of Immunology and Allergy pays non établi dans la noticeUniversité ou école supérieure
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Bam University of Medical Sciences Noncommunicable Diseases Research Center pays non établi dans la noticeUniversité ou école supérieure
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Kurdistan University of Medical Sciences Cellular and Molecular Research Center pays non établi dans la noticeUniversité ou école supérieure
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Mashhad University of Medical Sciences Department of Medical Biotechnology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Immunology and Allergy pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Department of Medical Biotechnology pays non établi dans la noticeUniversité ou école supérieure
University of Neyshabur, Department of Basic Medical Sciences — Neyshabur University of Medical Sciences et Center for Reference and Research on Rabies — Pasteur Institute of Iran, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.