Short‐term lung function changes predict mortality in patients with fibrotic hypersensitivity pneumonitis
Rattachement africain : gb, it, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND AND OBJECTIVE: A proportion of patients with fibrotic hypersensitivity pneumonitis (fHP) follow a progressive disease course despite immunosuppressive treatment. Little is known about predictors of mortality in fHP. We aimed to investigate the impact of short-term lung function changes in fHP on mortality. METHODS: Baseline demographics for 145 consecutive patients with a multi-disciplinary team diagnosis of fHP, as well as baseline and 1-year follow-up of lung function, baseline echocardiographic findings, bronchoalveolar lavage (BAL) cellularity and all-cause mortality were recorded. Changes in forced vital capacity (FVC) ≥ 5% and ≥10%, and diffusion capacity of the lung for carbon monoxide (DLCO) ≥ 10% and ≥15% at 1 year were calculated. Cox proportional hazards analysis was performed to test for associations with mortality. RESULTS: Baseline lung function severity, age, presence of honeycombing on computed tomography (CT) and echocardiographic pulmonary arterial systolic pressure (PASP) ≥ 40 mm Hg were associated with early mortality, while BAL lymphocytosis was associated with improved survival. A decline in FVC ≥ 5% (hazard ratio [HR]: 3.10, 95% CI: 2.00-4.81, p < 0.001), FVC ≥ 10% (HR: 3.11, 95% CI: 1.94-4.99, p < 0.001), DLCO ≥ 10% (HR: 2.80, 95% CI: 1.78-4.42, p < 0.001) and DLCO ≥ 15% (HR: 2.92, 95% CI: 1.18-4.72, p < 0.001) at 1 year was associated with markedly reduced survival on univariable and multivariable analyses after correcting for demographic variables, disease severity, honeycombing on CT and treatment, as well as BAL lymphocytosis and PASP ≥ 40 mm Hg on echocardiography, in separate models. CONCLUSION: Worsening in FVC and DLCO at 1 year, including a marginal decline in FVC ≥ 5% and DLCO ≥ 10%, is predictive of markedly reduced survival in fHP.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Short‐term lung function changes predict mortality in patients with fibrotic hypersensitivity pneumonitis
- Date Crossref
- 12/01/2022
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Guy's and St Thomas' NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
-
Istituto Nazionale di Riposo e Cura per Anziani pays non établi dans la noticeÉtablissement de santé
-
Imperial College London Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute pays non établi dans la noticeUniversité ou école supérieure
-
London North West Healthcare NHS Trust pays non établi dans la noticeÉtablissement de santé
-
University of Manchester pays non établi dans la noticeUniversité ou école supérieure
-
University of Southern California pays non établi dans la noticeUniversité ou école supérieure
-
Hastings Center pays non établi dans la noticeOrganisation à but non lucratif
-
"L.Mandic" Hospital Merate (LC) Merate Italy Department of Pneumology INRCA/IRCCS pays non établi dans la noticeÉtablissement de santé
-
Interstitial Lung Disease Unit Royal Brompton and Harefield Clinical Group Interstitial Lung Disease Unit pays non établi dans la noticeÉtablissement de santé
-
University of the Sacred Heart Rome Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario "A. Gemelli" – IRCCS pays non établi dans la noticeUniversité ou école supérieure
-
Department of Radiology Royal Brompton and Harefield Clinical Group pays non établi dans la noticeÉtablissement de santé
-
Faculty of Biology pays non établi dans la noticeUniversité ou école supérieure
Guy's and St Thomas' NHS Foundation Trust, Istituto Nazionale di Riposo e Cura per Anziani et Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute — Imperial College London, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.