When is the Ideal Time to Perform Brain MRI in Patients with Transient Global Amnesia? Analysis of Case Series with Transient Global Amnesia from Previous Studies, based on Imaging Findings of Diffusion MRI According to Time Criteria

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Objective: To determine the role of diffusion-weighted imaging (DWI) magnetic resonance studies in diagnosis of Transient Global Amnesia in patients who fulfilled the clinical diagnostic criteria. Methods:In this systemic review study, 214 patients from 17 previous studies, who fulfilled the clinical diagnostic criteria of transient global amnesia were analyzed, based on imaging findings of DWI MRI according to temporal criteria.PubMed was meticulously searched.Results: DWI findings in at least one hippocampus were found in 180 of 214 patients, regardless of the time the MRI performed.This accounted for the majority, 84.1%, of all patients who met the diagnostic criteria for TGA.Hippocampal DWI lesions were more common on the left one.The percentages of positive neuroimaging findings compared to the time the episode of TGA begins and the clinical signs are apparent as follows: 84,1% in general, 26%, when the examination is performed within the first day, 71,9% in approximately 24 hours, 87,2% at 36 hours, 82,3% at 48 hours, 72,7% at 72 hours, 42,8%, when performed in the first days but after 72 hours and 0%, when performed on a remote date, indicating the transient nature of the episode. Conclusion:According to the results of the present study, the best time to perform cranial MRI DWI seems to be between 36 to 48 hours after the initiation of the clinical semiology of transient global amnesia.

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