Impact of postoperative chemotherapy on survival for oesophagogastric adenocarcinoma after preoperative chemotherapy and surgery
Rattachement africain : gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Perioperative chemotherapy is widely used in the treatment of oesophagogastric adenocarcinoma (OGAC) with a substantial survival benefit over surgery alone. However, the postoperative part of these regimens is given in less than half of patients, reflecting uncertainty among clinicians about its benefit and poor postoperative patient fitness. This study estimated the effect of postoperative chemotherapy after surgery for OGAC using a large population-based data set. METHODS: Patients with adenocarcinoma of the oesophagus, gastro-oesophageal junction or stomach diagnosed between 2012 and 2018, who underwent preoperative chemotherapy followed by surgery, were identified from a national-level audit in England and Wales. Postoperative therapy was defined as the receipt of systemic chemotherapy within 90 days of surgery. The effectiveness of postoperative chemotherapy compared with observation was estimated using inverse propensity treatment weighting. RESULTS: Postoperative chemotherapy was given to 1593 of 4139 patients (38.5 per cent) included in the study. Almost all patients received platinum-based triplet regimens (4004 patients, 96.7 per cent), with FLOT used in 3.3 per cent. Patients who received postoperative chemotherapy were younger, with a lower ASA grade, and were less likely to have surgical complications, with similar tumour characteristics. After weighting, the median survival time after postoperative chemotherapy was 62.7 months compared with 50.4 months without chemotherapy (hazard ratio 0.84, 95 per cent c.i. 0.77 to 0.94; P = 0.001). CONCLUSION: This study has shown that postoperative chemotherapy improves overall survival in patients with OGAC treated with preoperative chemotherapy and surgery.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of postoperative chemotherapy on survival for oesophagogastric adenocarcinoma after preoperative chemotherapy and surgery
- Date Crossref
- 15/12/2021
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Royal College of Surgeons of England Clinical Effectiveness Unit pays non établi dans la noticeOrganisme public
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University of Southampton pays non établi dans la noticeUniversité ou école supérieure
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Velindre NHS Trust pays non établi dans la noticeÉtablissement de santé
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Oxford University Hospitals NHS Trust Department of Upper Gastrointestinal Surgery pays non établi dans la noticeÉtablissement de santé
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Sandwell & West Birmingham Hospitals NHS Trust pays non établi dans la noticeÉtablissement de santé
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School of Cancer Sciences pays non établi dans la noticeUniversité ou école supérieure
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Velindre University NHS Trust Department of Oncology pays non établi dans la noticeUniversité ou école supérieure
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Sandwell and West Birmingham Hospitals NHS Trust Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
Clinical Effectiveness Unit — Royal College of Surgeons of England, University of Southampton et Velindre NHS Trust, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.