DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies
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Le résumé fourni par la source
BACKGROUND: Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is unclear, many studies have pointed out the role of stress in this syndrome. DHEA, being a stress marker is being used by scientists to compare the stress levels between polycystic ovarian cases and healthy controls. However, the results obtained from previous studies are equivocal. OBJECTIVE: To perform meta-analysis and find the association between stress and the syndrome. DATA SOURCES: Relevant data till January 2021 were retrieved from PubMed, Scopus, Embase and Web of Science using MeSH terms. STUDY SELECTION: Case-control studies having PCOS subjects as cases and healthy women as controls were selected provided; their basal DHEA levels were mentioned in the published articles. DATA EXTRACTION: Two authors independently extracted the articles and qualified the final studies. DATA SYNTHESI: Pooled meta-analysis was done using random effect model and showed level of DHEA statistically significant in PCOS compared to healthy controls (SMD = 1.15, 95% CI = 0.59-1.71).Heterogeneity was statistically significant as well (I2 = 95%). CONCLUSION: Thismeta-analysis on DHEA and PCOS has helped in generating evidence regarding the involvement of stress in the pathogenesis of PCOS.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies
- Date Crossref
- 21/12/2021
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sri Ramachandra Institute of Higher Education and Research Department of Human Genetics pays non établi dans la noticeUniversité ou école supérieure
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Central Council for Research in Yoga & Naturopathy pays non établi dans la noticeStructure de recherche
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Narayana Dental College and Hospital pays non établi dans la noticeÉtablissement de santé
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Sri Ramachandra Medical College and Research Institute Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
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Government Yoga and Naturopathy Medical College and Hospital Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
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Narayana Medical College and Hospital Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
Department of Human Genetics — Sri Ramachandra Institute of Higher Education and Research, Central Council for Research in Yoga & Naturopathy et Narayana Dental College and Hospital, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.