The in vitro apoptotic effect of new zinc complex possessing folic acid and phenanthroline on cervix cancer cells
Rattachement africain : cn, ir. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract With proper care and nursing as well as timely diagnosis and good treatment, cervical cancer is one of the most treatable forms of cancer. One of the most important cancer treatments is the use of emerging developing metal–organic complexes, which can provide a wide variety of morphologies, sizes, and properties based on different metal ions and different organic ligands. Accordingly, we reported the synthesis method, structural properties, cytotoxicity, apoptotic properties, and molecular docking analysis of the new Zn(II) complex consisting of phenanthroline and folic acid ligands. FTIR, 1H‐NMR, 13C‐NMR, and elemental analyzer determined that the synthesis of the complex was successful. The IC50 values (380 and 199 μM) were shown that the viability of HeLa cells was dependent on time of exposure and concentration of [Zn(Phen)FA] complex. Real‐time PCR clearly shows increased expression of apoptotic genes in cervical carcinoma HeLa cells and a possible relationship between Bak1/Bclx ratio and caspase‐3. Also, the key amino acids of folate receptor that can interact with the synthesized complex were identified by molecular docking analysis. Moreover, molecular electrostatic potential confirmed that carboxylate portion of FA is an electron‐rich region and can interact with Zn(Phen) to form a stable and soluble complex. All experiments confirmed that presence of FA could improve stability, cytotoxicity, apoptosis, and cellular uptake of complex in cervical carcinoma HeLa cells.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The in vitro apoptotic effect of new zinc complex possessing folic acid and phenanthroline on cervix cancer cells
- Date Crossref
- 28/11/2021
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Henan Provincial People's Hospital Department of Obstetrics and Gynecology pays non établi dans la noticeÉtablissement de santé
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Zabol University of Medical Sciences Department of Medicinal Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Zabol University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy Department of Medicinal Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Department of Chemistry University of Zabol Zabol Iran Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
Department of Obstetrics and Gynecology — Henan Provincial People's Hospital, Department of Medicinal Chemistry — Zabol University of Medical Sciences et Zabol University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.