Risk of newly detected infections and cervical abnormalities in adult women seropositive or seronegative for naturally acquired HPV‐16/18 antibodies
Rattachement africain : be, au, mx, pe, nl, sg, ru, ca, gb, us, es. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background Infections with human papillomavirus (HPV) types 16 and 18 account for ~70% of invasive cervical cancers but the degree of protection from naturally acquired anti‐HPV antibodies is uncertain. We examined the risk of HPV infections as defined by HPV DNA detection and cervical abnormalities among women >25 years in the Human Papilloma VIrus Vaccine Immunogenicity ANd Efficacy trial's (VIVIANE, NCT00294047) control arm. Methods Serum anti‐HPV‐16/18 antibodies were determined at baseline and every 12 months in baseline DNA‐negative women (N = 2687 for HPV‐16 and 2705 for HPV‐18) by enzyme‐linked immunosorbent assay (ELISA) from blood samples. HPV infections were identified by polymerase chain reaction (PCR) every 6‐months, and cervical abnormalities were confirmed by cytology every 12 months. Data were collected over a 7‐year period. The association between the risk of type‐specific infection and cervical abnormalities and serostatus was assessed using Cox proportional hazard models. Results Risk of newly detected HPV‐16‐associated 6‐month persistent infections (PI) (hazard ratio [HR] = 0.56 [95%CI:0.32; 0.99]) and atypical squamous cells of undetermined significance (ASC‐US+) (HR = 0.28 [0.12; 0.67]) were significantly lower in baseline seropositive vs baseline seronegative women. HPV‐16‐associated incident infections (HR = 0.81 [0.56; 1.16]) and 12‐month PI (HR = 0.53 [0.24; 1.16]) showed the same trend. A similar trend of lower risk was observed in HPV‐18‐seropositive vs ‐seronegative women (HR = 0.95 [0.59; 1.51] for IIs, HR = 0.43 [0.16; 1.13] for 6‐month PIs, HR = 0.31 [0.07; 1.36] for 12‐month PIs, and HR = 0.61 [0.23; 1.61] for ASC‐US+). Conclusions Naturally acquired anti‐HPV‐16 antibodies were associated with a decreased risk of subsequent infection and cervical abnormalities in women >25 years. This possible protection was lower than that previously reported in 15‐ to 25‐year‐old women.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
Où se fait cette recherche
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GlaxoSmithKline (Belgium) pays non établi dans la noticeEntreprise
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The University of Sydney pays non établi dans la noticeUniversité ou école supérieure
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The Kids Research Institute Australia pays non établi dans la noticeOrganisation à but non lucratif
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Children's Hospital at Westmead pays non établi dans la noticeÉtablissement de santé
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Royal Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Royal Women's Hospital pays non établi dans la noticeÉtablissement de santé
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Murdoch Children's Research Institute pays non établi dans la noticeOrganisation à but non lucratif
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Mexican Social Security Institute pays non établi dans la noticeOrganisme public
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Instituto Nacional de Salud Pública pays non établi dans la noticeOrganisme public
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EsSALUD pays non établi dans la noticeInstitution
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The University of Western Australia pays non établi dans la noticeUniversité ou école supérieure
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Roosevelt Institute for American Studies pays non établi dans la noticeStructure de recherche
GlaxoSmithKline (Belgium), The University of Sydney et The Kids Research Institute Australia, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.