Assessment of xenon effect on postoperative pain syndrome severity in oncological patients: a randomized study

Le résumé fourni par la source

Introduction. The present study was designed to evaluate analgetic effect of xenon-oxygen mixture inhalations in oncological patients with abdominal tumors in postoperative period. Materials and methods. It was randomized blind placebo-controlled clinical trial, which was performed in 60 patients: 31 of them were in the main group and received xenon-oxygen mixture containing 25 ± 5 % xenon and other 29 were in the placebo group and received oxygen-air mixture. Results. According to the visual-analogical scale of pain, significant decreasing of the pain level was found in the main group after the inhalation and 30 minutes later in 90.3 % (p < 0.01) and 80.6 % of patients (p < 0.05) accordingly. The same result was found in the placebo group in 37.9 % of patients after oxygen-air mixture inhalation and 30 minutes later in 27.4 % of patients. The pain threshold measured with transcutaneal electroneurostimulation significantly increased in the xenon group after the inhalation (p < 0.01) and 30 minutes later (p < 0.05). In the placebo group no difference between the measurements was found. Conclusions. Xenon-oxygen mixture inhalation leads to the postoperative pain level reduction and increases the pain threshold in oncological patients.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.