Projecting vaccine demand and impact for emerging zoonotic pathogens
Rattachement africain : us, nl, no. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Despite large outbreaks in humans seeming improbable for a number of zoonotic pathogens, several pose a concern due to their epidemiological characteristics and evolutionary potential. To enable effective responses to these pathogens in the event that they undergo future emergence, the Coalition for Epidemic Preparedness Innovations is advancing the development of vaccines for several pathogens prioritized by the World Health Organization. A major challenge in this pursuit is anticipating demand for a vaccine stockpile to support outbreak response. We developed a modeling framework for outbreak response for emerging zoonoses under three reactive vaccination strategies. Annual vaccine regimen requirements for a population-wide strategy ranged from >670,000 (95% prediction interval: 0-3,630,000) regimens for Lassa virus to 1,190,000 (95% PrI: 0-8,480,000) regimens for Rift Valley fever virus, while the regimens required for ring vaccination or targeting healthcare workers (HCWs) were several orders of magnitude lower (between 1/25 and 1/700) than those required by a population-wide strategy. For each pathogen and vaccination strategy, reactive vaccination typically prevented fewer than 10% of cases, because of their presently low R0 values. Targeting HCWs had a higher per-regimen impact than population-wide vaccination. Our framework provides a flexible methodology for estimating vaccine stockpile needs and the geographic distribution of demand under a range of outbreak response scenarios.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Projecting vaccine demand and impact for emerging zoonotic pathogens
- Date Crossref
- 10/11/2021
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Notre Dame Department of Biological Sciences and Eck Institute for Global Health pays non établi dans la noticeUniversité ou école supérieure
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Wageningen University & Research pays non établi dans la noticeUniversité ou école supérieure
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Coalition for Epidemic Preparedness Innovations pays non établi dans la noticeStructure de recherche
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Gates Foundation pays non établi dans la noticeOrganisation à but non lucratif
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Wageningen University and Research Quantitative Veterinary Epidemiology pays non établi dans la noticeUniversité ou école supérieure
Department of Biological Sciences and Eck Institute for Global Health — University of Notre Dame, Wageningen University & Research et Coalition for Epidemic Preparedness Innovations, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.