Accès ouvert déclaré
2021
article
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
Thushan I. de Silva, Guihai Liu, Benjamin B. Lindsey, Danning Dong, Sharon Hsu, Dhruv R. Shah, Dannielle Wellington, Adrienn Angyal, Rebecca Brown, Matthew Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, David M. Aanensen, Khalil Abudahab, Helen Adams, Safiah Afifi, Dinesh Aggarwal, Shazaad S. Y. Ahmad, Louise Aigrain, Nabil-Fareed Alikhan, Roberto Amato, Tara Annett, Stephen Aplin, Cristina V. Ariani, Paula Ashfield, Carlos E. Balcazar, Rahul Batra, Nadua Bayzid, Angela H. Beckett, Shaun M. Beckwith, Luke Bedford, Robert Beer, Katherine L. Bellis, Louise Berry, Beatrice Bertolusso, Emma Betteridge, David C. Bibby, Debbie Binns, Victoria Blakey, Beth Blane, Frances Bolt, Stephen Bonner, Tim Boswell, Olivia Boyd, Cassie Breen, Judith Breuer, Stephen Bridgett, Iraad F. Bronner, Ellena Brooks, Matthew Bull, Phillipa Burns, Shirelle Burton-Fanning, Timothy Byaruhanga, Matthew Byott, Sharon L. Campbell, Alessandro M. Carabelli, Silvia Carvalho, Anna Casey, Nicola J. Chaloner, Meera Chand, Joseph Chappell, Themoula Charalampous, Wendy Chatterton, Yasmin Chaudhry, Jennifer Collins, Rachel Colquhoun, Thomas R. Connor, Sally Corden, Simon Cottrell, MacGregor Cox, Aidan Cross, Dorian Crudgington, Nicola Cumley, Tanya Curran, Gavin Dabrera, Robert M. Davies, Thomas P. Davis, Elen De Lacy, Leonardo de Oliveira Martins, Rebecca Dewar, Jayasree Dey, Matthew J. Dorman, Megan Driscoll, Jillian Durham, Jonathan Edgeworth, Sue Edwards, Nicholas Ellaby, Gary Eltringham, Michelle J. Erkiert, Marina Escalera Zamudio, William V. Everson, Arezou Fanaie, Christopher Fearn, Theresa Feltwell, Laia Fina, Vicki M. Fleming, Ebenezer Foster-Nyarko, Mireille Fragakis, Sarah François, Helen Fryer, William Fuller, Kavitha Gajee, Katerina Galai, Sharon Glaysher, Andrea N. Gomes, Sónia Gonçalves, Scott Goodwin, Marina Gourtovaia, Paul R. Grant, Martyn F. Guest, Ravi Gupta, William L. Hamilton, Tanzina Haque, Ewan M. Harrison, M J Harvey, Mohammed O. Hassan-Ibrahim, John Henderson, Jessica Hey, Ellen E. Higginson, Verity Hill, Nadine Holmes, Richard Hopes, Myra Hosmillo, Hannah Huckson, Joseph Hughes, Stephanie Hutchings, Giles Idle, Leigh Jackson, Victoria James, Keith James, Sarah Jeremiah, KATE JOHNSON, Owen Jones, Sophie Jones, Neil Jones, Amelia Joseph, Leanne M. Kermack, Stephen P. Kidd, Stuart A. Kirk, Christine Kitchen, Moritz U. G. Kraemer, Ken Laing, Deborah Lavin, Stefanie V. Lensing, Lisa J. Levett, Jonathan Lewis, Katie F. Loveson, Ronan A Lyons, Katrina Lythgoe, Nicholas W. Machin, Emily MacNaughton, Adhyana I. K. Mahanama, Cassandra S. Malone, Rocio T. Martinez Nunez, Patrick H. Maxwell, Megan Mayhew, Tamyo Mbisa, Shane McCarthy, J. T. McCrone, Nathan Medd, Ian Merrick, Stephen L. Michell, Michelle L. Michelsen, Mariyam Mirfenderesky, Emma Moles-Garcia, Siddharth Mookerjee, Helen Morcrette, Sian Morgan, Matilde Mori, Leanne J. Murray, Gaia Nebbia, Roberto Nicodemi, Kyriaki Nomikou, Natasha Ohemeng-Kumi, Richard Orton, Debra Padgett, Andrew J. Page, Emily J. Park, Surendra Parmar, David J. Pascall, Malorie Perry, Steven G. Platt, Manoj Baliram Pohare, Marcus Pond, Radoslaw Poplawski, Liam Prestwood, James Price, Jacqui Prieto, Sophie J. Prosolek, Monika Pusok, Jayna Raghwani, Diana Rajan, Shavanthi Rajatileka, Liz Ratcliffe, Veena Raviprakash, Sara Rey, David L. Robertson, Fiona Rogan, Will Rowe, Steven Rudder, Steven Rushton, Thea Sass, Garren Scott, Sharif Shaaban, Jessica Shaw, Liz A. Sheridan, Lesley Shirley, John Sillitoe, Siona Silviera, Timofey Skvortsov, Graciela Sluga, K. T. Smith, Kim S. Smith, Louise Smith, Karla Spellman, Michael H. Spencer Chapman, Lewis G. Spurgin, Moira Spyer, Malur Sudhanva, Emma Swindells, Ngee Keong Tan, Miao Tang, Joshua F. Taylor, Kate Templeton, Scott A. J. Thurston, L. Tong, Robyn Turnbull, Katherine A. Twohig, Edith E. Vamos, Tetyana I. Vasylyeva, Joanne Watkins, Louisa K. Watson, Hermione J. Webster, Max Whiteley, Andrew Whitwham, Lesley-Anne Williams, Chris Williams, Rachel Williams, Cheryl Williams, Eleri Wilson-Davies, Nick Wong, Trudy Workman, Victoria Wright, Tim Wyatt, Geraldine Yaze, Wen C. Yew, Gregory R. Young, Jamie Young, Malcolm G. Semple, Gail Carson, Petros Andrikopoulos, William Barclay, Kanta Chechi, G Cooke, Christopher Green, Julian L. Griffin, Samreen Ijaz, Sonia Liggi, Lynn Maslen, Mahdad Noursadeghi, Anthonia Osagie, Massimo Palmarini, William A. Paxton, Georgios Pollakis, Nicholas Price, J T Scott, Ryan S. Thwaites, Maria Zambon, Hayley Hardwick, Wilna Oosthuyzen, Stephanie Roberts, Marie Connor, Sophie Halpin, James Lee, Gary Leeming, Murray Wham, Sara Clohisey, Victoria Shaw, S. E. McDonald, Seán Keating, Samantha L Barlow, Laura Booth, Jordan J. Clark, Louise Cooper, Chris Dunn, Philip Dyer, Lorna Finch, Rebecca L. Jensen, Trevor R. Jones, Shadia Khandaker, Katharine King, Diane Latawiec, Lucia A Livoti, Maria Vittoria Mancini, Sarah McDonald, Soeren Metelmann, Joanna Middleton, Jack Pilgrim, Tessa Prince, Debby Sales, Rebecca K. Shears, Aislynn Taggart, Jordan Thomas, Jihui Zhang, Emily Cass, Nicola Carlucci, Hannah Massey, Nicola Wrobel, Kirstie Morrice, Kayode Adeniji, Ken Agwuh, Sam Allen, Shahedal Bari, Sneha Basude, John C. Berridge, Nicola Best, Tom Burden, Vikki Caruth, Duncan Chambler, Jenny Child, Srikanth Chukkambotla, Tom Clark, Maria-Teresa Cutino-Moguel, Phil Donnison, Ingrid DuRand, Chi Eziefula, Chrisopher Fegan, Adam Finn, Duncan Fullerton, Sanjeev Garg, Elaine Hardy, Peter Havalda, Michael E. Jacobs, Susan Jain, Paul B. Jennings, Vidya Kasipandian, Michael Kelsey, George Koshy, Shondipon Laha, Steven Laird, James Limb, Vanessa Linnett, Jeff Little, Ravish Mankregod, Katherine McCullough, Patrick Morgan, Katherine Mortimore, Mbiye Mpenge, Michael Murphy, Megan Nagel, Mark Nelson, Igor Otahal, Mark Pais, Selva Panchatsharam, Natalie Pattison, Justin Pepperell, Stefania Pintus, Nikolas Rae, Neil Richardson, Mark Roberts, Devender Roberts, Matthias L. Schmid, Prad Shanmuga, Anna Shawcross, Richard Smith, Nick Spittle, Tom Stambach, Pradeep Subudhi, Robert W. Thompson, Ascanio Tridente, Mary Twagira, Nick Vallotton, Rama Vancheeswaran, Shico Visuvanathan, Sam Waddy, Andrew Walden, Ingeborg Welters, Paul A. Whittaker, Meme Wijesinghe, Martin A. K. Williams, Stephen Winchester, P. A. Young, Yanchun Peng, Sarah L. Rowland-Jones
94Citations signalées — pas une note de qualité
18Institutions déclarées
5Pays d’affiliation déclarés
Résumé fourni par la source
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data.Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-g and cytotoxic killing assays.Complete loss of T cell responsiveness was seen due to Q213K in the A*01:01-restricted CD8+ ORF3a epitope FTSDYYQLY 207-215 ; due to P13L, P13S, and P13T in the B*27:05-restricted CD8+ nucleocapsid epitope QRNAP-RITF 9-17 ; and due to T362I and P365S in the A*03:01/A*11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK 361-369 .CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires.These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
- Date Crossref
- 01/11/2021
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesImmune responses and vaccinations