Anticonvulsant activity of leaf extract of Heinsia crinata : BIOLOGICAL ACTIVITY OF HEINSIA CRINATA

Résumé fourni par la source

Background: Heinsia crinata(Afzel). G. Tayl. (Rubiaceae), is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The anticonvulsant activity of the leaf extract was studied. Method: The ethanol leaf extract of H. crinata (450-1350 mg/kg) was investigated for anticonvulsant activity in mice against pentylenetetrazol, aminophylline and isoniazid-induced convulsion models to assess anticonvulsant activity. Results: The extract was found to significantly (p<0.005-0.01) and dose-dependently offered protection against PTZ-, aminophylline and isoniazid-induced convulsions in mice. Conclusion: The leaf extract of H. crinata possess anticonvulsant activity and this supports its use in ethnomedicine for the treatment of central nervous system disorders.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.