Accès ouvert déclaré 2021 review

Intraoperative Radiotherapy with Balloon-Based Electronic Brachytherapy System—A Systematic Review and First Bulgarian Experience in Breast Cancer Patients

Desislava Z. Kostova-Lefterova, Mariela Vasileva‐Slaveva, Svilen Maslyankov, Assia Konsoulova, Margarita Atanasova, Tsvetelina Paycheva, Alexandrina Ivanova Vlahova, Marusya Genadieva-Yordanova, Ginka Prodanova, Zahari Zahariev, Vasil Pavlov, Georgi Todorov, Boris Vasilev, Kostadin Angelov, Tashko S. Deliyski, Ivelina Petrova, Desislava Hitova, Ivo Spasov Petrov

5Citations signalées, ce qui n’est pas une note de qualité

6Institutions déclarées

1Pays d’affiliation déclarés

Rattachement africain : bg. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

(1) Background: We aimed to analyze currently available studies with intraoperative radiotherapy (IORT) as a choice of treatment where the Xoft Axxent® electronic brachytherapy (eBx) system was used as a single-dose irradiation and an exclusive radiotherapy approach at the time of surgery in patients with early breast cancer (EBC). We also compared the results of the systematic review to the Bulgarian experience. (2) Methods and Materials: We performed a systematic review of the studies published before February 2021, which investigate the application of a single-fraction 20 Gy radiation treatment, delivered at the time of lumpectomy in EBC patients with the Xoft Axxent® eBx System. A systematic search in PubMed, Scopus, and ScienceDirect was performed. The results are reported following the PRISMA guidelines. The criteria on patients’ selection for IORT (the additional need for EBRT), cosmetic outcomes, and recurrence rate from the eligible studies are compared to the treatment results in Bulgarian patients. (3) Results: We searched through 1032 results to find 17 eligible studies. There are no published outcomes from randomized trials. When reported, the cosmetic outcomes in most of the studies are defined as excellent. The observed recurrence rate is low (1–5.8%). Still, the number of patients additionally referred to postoperative external breast radiotherapy (EBRT) is up to 31%. Amongst the 20 patients treated in Bulgaria, the cosmetic outcomes are also evaluated as excellent, five of which (25%) are referred for EBRT. Within median follow-up of 39 months, there was one local and one distal recurrence. (4) Conclusions: Current evidence demonstrates the Xoft Axxent® eBx system as a safe and feasible technique for IORT delivery in EBC patients. There are no randomized controlled trials conducted at this time point to prove its long-term effectiveness. Better patient selection and a reimbursement strategy have to be proposed to extend the application of this technique in Bulgaria.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Intraoperative Radiotherapy with Balloon-Based Electronic Brachytherapy System—A Systematic Review and First Bulgarian Experience in Breast Cancer Patients
Date Crossref: 03/10/2021
Éditeur: MDPI AG
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Medical University Pleven pays non établi dans la notice
Université ou école supérieure
Acibadem City Clinic Department of Surgery pays non établi dans la notice
Établissement de santé
Alexandrovska Hospital pays non établi dans la notice
Établissement de santé
Military Medical Academy pays non établi dans la notice
Établissement de santé
University Hospital Dr. Georgi Stranski pays non établi dans la notice
Établissement de santé
University of Telecommunications and Post Department of Basic Training pays non établi dans la notice
Université ou école supérieure
Medical University—Pleven Department of Medical Diagnostic Activities pays non établi dans la notice
Université ou école supérieure
Women for Oncology—Bulgaria pays non établi dans la notice
Institution
Alexandrovska University Hospital Department of Surgery pays non établi dans la notice
Université ou école supérieure
Department of Medical Oncology pays non établi dans la notice
Institution
Department of Surgery pays non établi dans la notice
Institution
Uni Hospital Department of Radiotherapy pays non établi dans la notice
Établissement de santé

Medical University Pleven, Department of Surgery — Acibadem City Clinic et Alexandrovska Hospital, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Breast Cancer Treatment StudiesAdvanced Radiotherapy TechniquesAngiogenesis and VEGF in Cancer

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