Effect of steroid hormone receptor gene variants PROGINS (Alu insertion) and PGR C/T (rs1042839) as a risk factor for recurrent pregnancy loss in Kashmiri population (North India)
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Le résumé fourni par la source
AIM: To unveil and evaluate the association and analyze the incidence and pattern of PGR gene polymorphisms (PROGINS insertion and PGR exon 5-C/T polymorphism) in recurrent pregnancy loss (RPL) couples of Kashmir. METHODS: In this study, analyses of PGR gene polymorphisms in RPL couples were genotyped by amplification-refractory mutation system polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism. RESULTS: Molecular analysis of PGR gene polymorphisms indicated that the genotypic and allelic frequencies of PROGINS insertion and PGR exon 5 C/T polymorphisms of female group in cases and controls to be significantly different and poses risk in predisposition to RPL. Moreover, haplotype analysis in female group revealed that P1P2/CC and P1P2/CT genotype are significantly associated with RPL. CONCLUSION: Our data indicate that the PROGINS insertion and exon 5-C/T polymorphism can act as useful genetic markers in the female group, but needs to be replicated in further studies including various other single nucleotide polymorphisms of PGR gene relevant to pregnancy loss which may contribute to novel therapeutic targets with improved conclusions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Effect of steroid hormone receptor gene variants <scp><i>PROGINS</i></scp> (Alu insertion) and <scp><i>PGR</i></scp> C/T (rs1042839) as a risk factor for recurrent pregnancy loss in Kashmiri population (North India)
- Date Crossref
- 09/10/2021
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sher-i-Kashmir Institute of Medical Sciences Department of Advanced Centre for Human Genetics pays non établi dans la noticeUniversité ou école supérieure
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Jaipur National University Department of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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Department of Advanced Centre for Human Genetics Sher‐I‐Kashmir Institute of Medical Sciences Srinagar India pays non établi dans la noticeStructure de recherche
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Department of Gynaecology and Obstetrics Sher‐I‐Kashmir Institute of Medical Sciences Srinagar India pays non établi dans la noticeStructure de recherche
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Department of Endocrinology Sher‐I‐Kashmir Institute of Medical Sciences Srinagar India pays non établi dans la noticeStructure de recherche
Department of Advanced Centre for Human Genetics — Sher-i-Kashmir Institute of Medical Sciences, Department of Life Sciences — Jaipur National University et Department of Advanced Centre for Human Genetics Sher‐I‐Kashmir Institute of Medical Sciences Srinagar India, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.