Modelling sexual violence in male rats: The sexual aggression test (SxAT)
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Le résumé fourni par la source
Abstract Sexual assault and rape are crimes that impact victims worldwide. Although the psychosocial and eco-evolutionary factors associated with this antisocial behavior have repeatedly been studied, the underlying neurobiological mechanisms are still unknown mainly due to the lack of an appropriate animal model of sexual aggression (SxA). Here, we established a novel paradigm to provoke and subsequently assess SxA in adult male Wistar rats: the sexual aggression test (SxAT). Briefly, male Wistar rats are sexually aroused by a receptive female, which is exchanged by a non-receptive female immediately after the first intromission. This protocol elicits forced mounting (FM) and aggressive behavior (AB) towards the non-receptive female to different degrees, which can be scored. In a series of experiments we can show that SxA behavior is a relatively stable trait in rats and correlates positively with sexual motivation. Rats with innate abnormal anxiety and aggressive behavior also show abnormal SxA behavior. In addition, central infusion of oxytocin moderately inhibits AB, but increases FM. Finally, we identified the agranular insular cortex to be specifically activated by SxA, and inhibition of this region mildly decreased AB during the SxAT. Altogether, the SxAT is a paradigm that can be readily implemented in behavioral laboratories as a valuable tool to find answers regarding the biological mechanisms underlying SxA in humans, as well as social decision-making in general.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Modelling sexual violence in male rats: The sexual aggression test (SxAT)
- Date Crossref
- 07/10/2021
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Liège Laboratory of Neuroendocrinology pays non établi dans la noticeUniversité ou école supérieure
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Institute of Neurobiology pays non établi dans la noticeStructure de recherche
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University of Regensburg Department of Neurobiology and Animal Physiology pays non établi dans la noticeUniversité ou école supérieure
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Verslavingszorg Noord Nederland pays non établi dans la noticeÉtablissement de santé
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Medische Biobank Noord-Nederland B.V. Groningen pays non établi dans la noticeInstitution
Laboratory of Neuroendocrinology — University of Liège, Institute of Neurobiology et Department of Neurobiology and Animal Physiology — University of Regensburg, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.