Characterizing academic performance in pediatric acute lymphoblastic leukemia with population‐based achievement tests
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Le résumé fourni par la source
BACKGROUND: Recent shifts from radiation to chemotherapy-based treatment for acute lymphoblastic leukemia (ALL) have contributed to reduced long-term morbidity. Despite this, ALL survivors remain at increased risk for long-term cognitive impairments. AIM: To identify demographic and treatment factors associated with school performance in pediatric survivors of ALL. METHODS: We collected standardized test scores for reading, math, and science obtained in a school setting from grades 3-11 in 63 ALL survivors (46.0% boys). Most participants were assessed across multiple grades (median number of grades n = 5, range 1-7), and 269 observations were considered in the analyses. Treatment exposures were extracted from medical records. Socio-economic status was estimated using participation in free/reduced lunch programs at school. Mixed effects linear regression models were conducted to determine factors associated with school performance. RESULTS: ALL survivors' scores were comparable to state norms on reading, math, and science performances. On multivariable analysis, participation in free/reduced lunch programs was significantly associated with lower reading scores (β = -12.52; 95% CI -22.26:-2.77, p = .01). Exposure to radiation during treatment was also associated with lower reading test scores (β = -30.81, 95% CI -52.00:-9.62, p = .01). No significant associations between demographics and treatment parameters were observed for math and science test scores. CONCLUSIONS: We utilized population-based achievement tests conducted from grades 3-11 to characterize school performance in ALL survivors. Our results imply that survivors with low socio-economic status and those exposed to radiation during treatment could benefit from early monitoring and intervention to maximize academic success.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Characterizing academic performance in pediatric acute lymphoblastic leukemia with population‐based achievement tests
- Date Crossref
- 30/09/2021
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Iowa Hospitals and Clinics pays non établi dans la noticeÉtablissement de santé
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University of Florida Health Department of Health Education and Behavior pays non établi dans la noticeUniversité ou école supérieure
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University of Arkansas for Medical Sciences Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Department of Psychiatry University of Iowa Hospital and Clinics Iowa City Iowa USA Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Holden Comprehensive Cancer Center University of Iowa Hospital and Clinics Iowa City Iowa USA pays non établi dans la noticeUniversité ou école supérieure
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Stead Family Department of Pediatrics University of Iowa Hospital and Clinics Iowa City Iowa USA pays non établi dans la noticeUniversité ou école supérieure
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Department of Health Education and Behavior University of Florida Gainesville Florida USA pays non établi dans la noticeUniversité ou école supérieure
University of Iowa Hospitals and Clinics, Department of Health Education and Behavior — University of Florida Health et Department of Pediatrics — University of Arkansas for Medical Sciences, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.