Crocin treatment improves testosterone induced benign prostatic hyperplasia in rats
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Le résumé fourni par la source
Background and objective: Benign prostatic hyperplasia (BPH) is a typical nonmalignant growth of the prostate in the elderly. Crocin, a bioactive component of Crocus sativus L., commonly known as saffron, is known to have an anti-proliferative activity against numerous types of cancer, including prostate cancer. This study investigated the effects of crocin on testosterone-induced BPH development in rats. Materials and methods: The study sample included three groups of adult male rats (3 months old, weighed 250 g): the control group received corn oil only, the second and the third groups were injected with testosterone (3 mg/kg dissolved in corn oil) subcutaneously. The second group was considered as testosterone-induced BPH (untreated) while the third groups were assigned as testosterone-induced BPH-crocin treated group (100 mg/kg orally for 14 days). Results: After animal sacrifice, histopathological analysis of the prostate tissues was performed in parallel with gene expression of proliferation (PCNA), inflammation (IL-6), and vascularization (VEGF-A) markers, analyzed by qRT-PCR. Crocin treatment significantly reduced prostate index and the thickness of the epithelial layer in rats with BPH. Additionally, the mRNA expression levels of PCNA, a marker of cell proliferation; IL-6, an inflammatory cytokine; and VEGF-A, an angiogenesis marker, were significantly down-regulated in the BPH group that were treated with crocin. Conclusions: The present study indicates that crocin can effectively prevent the development of experimentally induced BPH through inhibition of prostatic cellular proliferation, inflammation, and angiogenesis.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Crocin treatment improves testosterone induced benign prostatic hyperplasia in rats
- Date Crossref
- 18/09/2021
- Éditeur
- MRE Press
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Yarmouk University pays non établi dans la noticeUniversité ou école supérieure
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Rowan University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Science Department of Biological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Basic Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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College of Science and Mathematics Department of Biological Sciences pays non établi dans la noticeUniversité ou école supérieure
Yarmouk University, Rowan University et Department of Biological Sciences — Faculty of Science, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.