From first to second wave: follow-up of the prospective COVID-19 cohort (KoCo19) in Munich (Germany)
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Le résumé fourni par la source
BACKGROUND: In the 2nd year of the COVID-19 pandemic, knowledge about the dynamics of the infection in the general population is still limited. Such information is essential for health planners, as many of those infected show no or only mild symptoms and thus, escape the surveillance system. We therefore aimed to describe the course of the pandemic in the Munich general population living in private households from April 2020 to January 2021. METHODS: The KoCo19 baseline study took place from April to June 2020 including 5313 participants (age 14 years and above). From November 2020 to January 2021, we could again measure SARS-CoV-2 antibody status in 4433 of the baseline participants (response 83%). Participants were offered a self-sampling kit to take a capillary blood sample (dry blood spot; DBS). Blood was analysed using the Elecsys® Anti-SARS-CoV-2 assay (Roche). Questionnaire information on socio-demographics and potential risk factors assessed at baseline was available for all participants. In addition, follow-up information on health-risk taking behaviour and number of personal contacts outside the household (N = 2768) as well as leisure time activities (N = 1263) were collected in summer 2020. RESULTS: Weighted and adjusted (for specificity and sensitivity) SARS-CoV-2 sero-prevalence at follow-up was 3.6% (95% CI 2.9-4.3%) as compared to 1.8% (95% CI 1.3-3.4%) at baseline. 91% of those tested positive at baseline were also antibody-positive at follow-up. While sero-prevalence increased from early November 2020 to January 2021, no indication of geospatial clustering across the city of Munich was found, although cases clustered within households. Taking baseline result and time to follow-up into account, men and participants in the age group 20-34 years were at the highest risk of sero-positivity. In the sensitivity analyses, differences in health-risk taking behaviour, number of personal contacts and leisure time activities partly explained these differences. CONCLUSION: The number of citizens in Munich with SARS-CoV-2 antibodies was still below 5% during the 2nd wave of the pandemic. Antibodies remained present in the majority of SARS-CoV-2 sero-positive baseline participants. Besides age and sex, potentially confounded by differences in behaviour, no major risk factors could be identified. Non-pharmaceutical public health measures are thus still important.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- From first to second wave: follow-up of the prospective COVID-19 cohort (KoCo19) in Munich (Germany)
- Date Crossref
- 08/09/2021
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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LMU Klinikum pays non établi dans la noticeÉtablissement de santé
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German Center for Lung Research pays non établi dans la noticeStructure de recherche
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Ludwig-Maximilians-Universität München pays non établi dans la noticeUniversité ou école supérieure
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Bielefeld University pays non établi dans la noticeUniversité ou école supérieure
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Helmholtz Munich pays non établi dans la noticeStructure de recherche
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German Center for Infection Research pays non établi dans la noticeStructure de recherche
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Technical University of Munich pays non établi dans la noticeUniversité ou école supérieure
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Universität der Bundeswehr München pays non établi dans la noticeUniversité ou école supérieure
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Institut für Mikrobiologie der Bundeswehr pays non établi dans la noticeStructure de recherche
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University of Bonn Interdisciplinary Research Unit Mathematics and Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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Life & Brain (Germany) pays non établi dans la noticeEntreprise
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University Hospital Center for International Health (CIH) pays non établi dans la noticeUniversité ou école supérieure
LMU Klinikum, German Center for Lung Research et Ludwig-Maximilians-Universität München, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.