Accès ouvert déclaré 2021 preprint

Testing Denmark: A Danish nationwide surveillance study of COVID-19

Kamille Fogh, Jarl Emanuel Strange, Bibi FSS Scharff, Alexandra R. R. Eriksen, Rasmus Bo Hasselbalch, Henning Bundgaard, Susanne Dam Nielsen, Charlotte Sværke Jørgensen, Christian Erikstrup, Jakob Boesgaard Norsk, Pernille Brok Nielsen, Jonas Henrik Kristensen, Lars Jørgen Østergaard, Svend Ellermann‐Eriksen, Berit Sanne Andersen, Henrik Ib Nielsen, Işık Somuncu Johansen, Lothar Wiese, Lone Simonsen, Thea Kølsen Fischer, Fredrik Folke, Freddy Knudsen Lippert, Sisse Rye Ostrowski, Thomas Benfield, Kåre Mølbak, Steen Ethelberg, Anders Koch, Ute Wolff Sönksen, Anne‐Marie Vangsted, Tyra Grove Krause, Anders Fomsgaard, Henrik Ullum, Robert Leo Skov, Kasper Karmark Iversen

7Citations signalées, ce qui n’est pas une note de qualité

11Institutions déclarées

1Pays d’affiliation déclarés

Rattachement africain : dk. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Abstract Background National data on the spread of SARS-CoV-2 infection and knowledge on associated risk factors are important for understanding the course of the pandemic. “Testing Denmark” is a national large-scale epidemiological surveillance study of SARS-CoV-2 in the Danish population. Methods Between September and October 2020, approximately 1.3 million of 5.8 million Danish citizens (age > 15 years) were randomly invited to fill in an electronic questionnaire covering COVID-19 exposures and symptoms. The prevalence of SARS-CoV-2 antibodies was determined by Point-of Care rapid Test (POCT) distributed to participants home addresses. Findings In total 318,552 participants (24.5% invitees) completed the questionnaire and provided the result of the POCT. Of these, 2,519 (0.79%) were seropositive (median age 55 years) and women were more often seropositive than men, interquartile range (IQR) 42-64, 40.2% males. Of participants with a prior positive Polymerase Chain Reaction (PCR) test (n=1,828), 29.1% were seropositive in the POCT. Seropositivity increased with age irrespective of sex. Elderly participants (>61 years) reported less symptoms and had less frequently been tested for SARS-CoV-2 compared to younger participants. Seropositivity was associated with physical contact with SARS-CoV-2 infected individuals (Risk ratio (RR) 7.43, 95% CI: 6.57-8.41) and in particular household members (RR 17.70, 95% CI: 15.60-20.10). Home care workers had a higher risk of seropositivity (RR 2.09 (95% CI: 1.58-2.78) as compared to office workers. Geographic population density was not associated to seropositivity. A high degree of compliance with national preventive recommendations was reported (e.g., > 80% use of face masks), but no difference was found between seropositive and seronegative participants. Interpretation This study provides insight into the immunity of the Danish population seven to eight months after the first COVID-19 case in Denmark. The seroprevalence was lower than expected probably due to a low sensitivity of the POCT used or due to challenges relating to the reading of test results. Occupation or exposure in local communities were major routes of infection. As elderly participants were more often seropositive despite fewer symptoms and less PCR tests performed, more emphasis should be placed on testing this age group.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Testing Denmark: A Danish nationwide surveillance study of COVID-19
Date Crossref: 13/08/2021
Éditeur: openRxiv
Type: posted-content

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Gentofte Hospital pays non établi dans la notice
Établissement de santé
Copenhagen University Hospital Department of Cardiology pays non établi dans la notice
Établissement de santé
Rigshospitalet pays non établi dans la notice
Établissement de santé
Statens Serum Institut pays non établi dans la notice
Structure de recherche
Aarhus University Hospital Department of Infectious Diseases pays non établi dans la notice
Établissement de santé
Regional Hospital Randers pays non établi dans la notice
Établissement de santé
Aalborg University Hospital Department of Infectious Diseases pays non établi dans la notice
Établissement de santé
Odense University Hospital Department of Infectious Diseases pays non établi dans la notice
Organisme public
Zealand University Hospital Department of Infectious Diseases pays non établi dans la notice
Établissement de santé
Roskilde University Department of Science and Environment pays non établi dans la notice
Université ou école supérieure
Hvidovre Hospital pays non établi dans la notice
Établissement de santé
University Research Clinic for Cancer Screening pays non établi dans la notice
Université ou école supérieure

Gentofte Hospital, Department of Cardiology — Copenhagen University Hospital et Rigshospitalet, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 epidemiological studies

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