Impact of dietary aflatoxin on immune development in Gambian infants: a cohort study
Rattachement africain : gb, Gambie, cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Chronic aflatoxin (AF) exposure has been shown to occur at high levels in children from sub-Saharan Africa (SSA), and has been associated with growth retardation and immune dysfunction. Our objective was to investigate the impact of AF exposure on immune development in early infancy using thymic size and antibody (Ab) response to vaccination as indicators of immune function. METHODS: A total of 374 infants born between May 2011 and December 2012 were enrolled into the current study. These infants were recruited from a larger, randomised trial examining the impact of nutritional supplementation of mothers and infants on infant immune development (the Early Nutrition and Immune Development Trial). Thymic size (Thymic Index, TI) was measured by sonography at 1 week, 8 weeks, 24 weeks and 52 weeks of infant age. Infants were given the diphtheria-tetanus-pertussis (DTP) vaccine at 8 weeks, 12 weeks and 16 weeks of age, and Ab responses to each vaccine measured at 12 weeks and 24 weeks of age. AF-albumin (AF-alb) adduct levels in infant blood were measured by ELISA as the biomarker of AF exposure. RESULTS: The geometric mean (GM) level of AF-alb increased with age. Only half of infants had detectable AF-alb with a GM of 3.52 pg/mg at 24 weeks, increasing to 25.39 pg/mg at 52 weeks, when 98% of infants had AF-alb >limit of detection. Significant negative association of AF-alb level with TI was seen in infants during the first 24 weeks, especially at 8 weeks of age (p<0.001), which is the time point of fastest thymus growth. There were no associations between AF exposure level and Ab response to pertussis and tetanus, but a significant positive correlation was observed between AF-alb level and Ab titre to diphtheria (p<0.005). CONCLUSIONS: High levels of AF exposure during early infancy may impact on infant immune development. TRIAL REGISTRATION NUMBER: ISRCTN49285450.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of dietary aflatoxin on immune development in Gambian infants: a cohort study
- Date Crossref
- 01/07/2021
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
University of Leeds pays non établi dans la noticeUniversité ou école supérieure
-
King's College London Department of Women and Children's Health pays non établi dans la noticeUniversité ou école supérieure
-
Queen's University Belfast pays non établi dans la noticeUniversité ou école supérieure
-
MRC Unit the Gambia Banjul, Gambie (code pays fourni par la source)Structure de recherche
-
Jiangsu University pays non établi dans la noticeUniversité ou école supérieure
-
School of Medicine pays non établi dans la noticeUniversité ou école supérieure
-
School of Food Science and Nutrition pays non établi dans la noticeUniversité ou école supérieure
-
School of Food and Biological Engineering pays non établi dans la noticeUniversité ou école supérieure
University of Leeds, Department of Women and Children's Health — King's College London et Queen's University Belfast, avec 5 autres affiliations. Pays d’affiliation : Gambie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.