The Association of Gut Microbiota With Osteoporosis Is Mediated by Amino Acid Metabolism: Multiomics in a Large Cohort
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Le résumé fourni par la source
CONTEXT: Several small studies have suggested that the gut microbiome might influence osteoporosis, but there is little evidence from human metabolomics studies to explain this association. OBJECTIVE: This study examined the association of gut microbiome dysbiosis with osteoporosis and explored the potential pathways through which this association occurs using fecal and serum metabolomics. METHODS: We analyzed the composition of the gut microbiota by 16S rRNA profiling and bone mineral density using dual-energy X-ray absorptiometry in 1776 community-based adults. Targeted metabolomics in feces (15 categories) and serum (12 categories) were further analyzed in 971 participants using ultra-high-performance liquid chromatography coupled to tandem mass spectrometry. RESULTS: This study showed that osteoporosis was related to the beta diversity, taxonomy, and functional composition of the gut microbiota. The relative abundance of Actinobacillus, Blautia, Oscillospira, Bacteroides, and Phascolarctobacterium was positively associated with osteoporosis. However, Veillonellaceae other, Collinsella, and Ruminococcaceae other were inversely associated with the presence of osteoporosis. The association between microbiota biomarkers and osteoporosis was related to levels of peptidases and transcription machinery in microbial function. Fecal and serum metabolomics analyses suggested that tyrosine and tryptophan metabolism and valine, leucine, and isoleucine degradation were significantly linked to the identified microbiota biomarkers and to osteoporosis, respectively. CONCLUSION: This large population-based study provided robust evidence connecting gut dysbiosis, fecal metabolomics, and serum metabolomics with osteoporosis. Our results suggest that gut dysbiosis and amino acid metabolism could be targets for intervention in osteoporosis.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Association of Gut Microbiota With Osteoporosis Is Mediated by Amino Acid Metabolism: Multiomics in a Large Cohort
- Date Crossref
- 02/07/2021
- Éditeur
- The Endocrine Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sun Yat-sen University pays non établi dans la noticeUniversité ou école supérieure
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Westlake University pays non établi dans la noticeUniversité ou école supérieure
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Zhujiang Hospital pays non établi dans la noticeÉtablissement de santé
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Southern Medical University Division of Laboratory Medicine pays non établi dans la noticeUniversité ou école supérieure
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Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences pays non établi dans la noticeStructure de recherche
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University of Cambridge MRC Epidemiology Unit pays non établi dans la noticeUniversité ou école supérieure
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MRC Epidemiology Unit pays non établi dans la noticeStructure de recherche
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School of Public Health Guangdong Provincial Key Laboratory of Food pays non établi dans la noticeUniversité ou école supérieure
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Guangdong Provincial Key Laboratory of Food pays non établi dans la noticeStructure de recherche
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School of Life Sciences Zhejiang Provincial Laboratory of Life Sciences and Biomedicine pays non établi dans la noticeUniversité ou école supérieure
Sun Yat-sen University, Westlake University et Zhujiang Hospital, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.