Predictive Ability of Procalcitonin for Acute Kidney Injury: A Narrative Review Focusing on the Interference of Infection
Rattachement africain : tw. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Acute kidney injury (AKI) is a common yet complicated clinical entity with high morbidity and mortality. An essential strategy to improve AKI patients' prognoses is finding optimal biomarkers to identify AKI in a timely manner. Procalcitonin (PCT), a well-recognized biomarker for diagnosing infection and guiding antibiotics therapy, has been proposed to predict AKI development and recovery in many clinical settings. The current review provides comprehensive and updated information from relevant studies to evaluate PCT's AKI-predictive ability and the influence of infection on this predictive ability. PCT has demonstrated optimal predictive ability for AKI in various populations irrespective of infection. However, the predictive ability seems to be blunted by infection since infection and inflammation have a more potent influence than AKI on PCT elevation. We furthermore explain the complicated association between elevated PCT levels and AKI in infection and inflammation situations and recommend directions for further investigations to clarify the essential issue. In conclusion, although conflicting data exist, serum PCT level is a potential biomarker for predicting AKI in many clinical settings regardless of infection. Nevertheless, further studies are warranted to clarify the association between PCT, infection, and AKI and to confirm the utilization of PCT for AKI prediction.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Predictive Ability of Procalcitonin for Acute Kidney Injury: A Narrative Review Focusing on the Interference of Infection
- Date Crossref
- 27/06/2021
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chung Hwa University of Medical Technology Department of Biological Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Chi Mei Medical Center Department of Nephrology pays non établi dans la noticeÉtablissement de santé
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Saint Mary's Hospital Luodong Department of Nursing pays non établi dans la noticeÉtablissement de santé
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National Taiwan University Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Saint Mary’s Junior College of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Biological Science and Technology — Chung Hwa University of Medical Technology, Department of Nephrology — Chi Mei Medical Center et Department of Nursing — Saint Mary's Hospital Luodong, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.