Cyclohexanone Exposure in Children on Extracorporeal Membrane Oxygenation Support
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Le résumé fourni par la source
The aim of this study was to determine if plasma cyclohexanone and metabolites are associated with clinical outcomes of children on extracorporeal membrane oxygenation (ECMO) support. We performed a secondary analysis of a prospective observational study of children on ECMO support at two academic centers between July 2010 and June 2015. We measured plasma cyclohexanone and metabolites on the first and last days of ECMO support. Unfavorable outcome was defined as in-hospital death or discharge Pediatric Cerebral Performance Category score > 2 or decline ≥ 1 from baseline. Among 90 children included, 49 (54%) had unfavorable outcome at discharge. Cyclohexanediol, a cyclohexanone metabolite, was detected in all samples and at both time points; concentrations on the first ECMO day were significantly higher in those with unfavorable versus favorable outcome at hospital discharge (median, 5.7 ng/µl; interquartile range [IQR], 3.3-10.6 ng/µl vs. median, 4.2 ng/µl; IQR, 1.7-7.3 ng/µl; p = 0.04). Twofold higher cyclohexanediol concentrations on the first ECMO day were associated with increased risk of unfavorable outcome at hospital discharge (multivariable-adjusted hazard ratio [HR], 1.24 [95% CI, 1.05-1.48]). Higher cyclohexanediol concentrations on the first ECMO day were not significantly associated with new abnormal neuroimaging or 1-year Vineland Adaptive Behavior Scales-II score < 85 or death among survivors.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cyclohexanone Exposure in Children on Extracorporeal Membrane Oxygenation Support
- Date Crossref
- 12/05/2021
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Johns Hopkins University Department of Physical Medicine and Rehabilitation pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Medicine pays non établi dans la noticeÉtablissement de santé
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Children's National Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Kennedy Krieger Institute pays non établi dans la noticeOrganisation à but non lucratif
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Johns Hopkins All Children's Hospital Molecular Determinants Core pays non établi dans la noticeÉtablissement de santé
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Johns Hopkins School of Medicine Department of Anesthesiology and Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Bloomberg School of Public Health Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
Department of Physical Medicine and Rehabilitation — Johns Hopkins University, Johns Hopkins Medicine et Department of Pediatrics — Children's National, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.