Hypericum triquetrifolium and H. neurocalycinum as Sources of Antioxidants and Multi-Target Bioactive Compounds: A Comprehensive Characterization Combining In Vitro Bioassays and Integrated NMR and LC-MS Characterization by Using a Multivariate Approach
Rattachement africain : it, tr, Maurice. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Hypericum triquetrifoliumandH. neurocalycinumwere evaluated for their phytochemical content andin vitrobioactivity. NMR analyses were performed on the methanol extract of the aerial parts ofH. triquetrifoliumto establish the main classes of phytoconstituents. Then, LC-DAD-MSnanalyses were performed in order to compare the composition of aerial parts and roots extracts of bothHypericumspecies, obtained using either methanol or water as solvents. Results, processed using multivariate data analysis, showed a significantly higher phenolic content of methanol extracts compared to water extracts, while minor qualitative differences were observed between the two. Distinctive flavonoid and PAC patterns were observed forH. triquetrifoliumandH. neurocalycinum, and specific compounds were exclusively detected in one or the other species. Specifically, the phloroglucinols 7-epiclusianone, hyperfirin and hyperforin were present only inH. neurocalycinum,while hyperforin was detected only inH. triquetrifolium.Extracts were assayed using differentin vitrotests to evaluate their antioxidant properties and their inhibitory activity against several enzymes, showing significant antioxidant and metal chelating activities. Furthermore, inhibitory properties against acetylcholinesterase, butyrylcholinesterase and tyrosinase were observed. Multivariate approaches were used to correlate biological data with the phytochemical composition of the different extracts. The results, showing positive correlations between specific chemical constituents and the measured bioactivities, represent preliminary data that could guide future studies aimed at isolating bioactive constituents fromH. neurocalycinumandH. triquetrifoliumfor further pharmacological evaluations.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Hypericum triquetrifolium and H. neurocalycinum as Sources of Antioxidants and Multi-Target Bioactive Compounds: A Comprehensive Characterization Combining In Vitro Bioassays and Integrated NMR and LC-MS Characterization by Using a Multivariate Approach
- Date Crossref
- 26/03/2021
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Padua pays non établi dans la noticeUniversité ou école supérieure
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Selçuk University pays non établi dans la noticeUniversité ou école supérieure
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University of Mauritius Maurice (code pays fourni par la source)Université ou école supérieure
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University of Padova Department of Pharmaceutical and Pharmacological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Science Faculty Department of Biology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine and Health Sciences Department of Health Sciences Maurice (pays nommé en fin d’affiliation)Université ou école supérieure
University of Padua, Selçuk University et University of Mauritius (Maurice), avec 3 autres affiliations. Pays d’affiliation : Maurice.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.