Cortisol and polycystic ovarian syndrome – a systematic search and meta-analysis of case–control studies
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Le résumé fourni par la source
Background Polycystic ovarian syndrome (PCOS) has become an emerging disorder affecting women of reproductive age group. Its intricate presentation of signs and symptoms makes it a disease of interest to research. While there are varied hypotheses related to its cause and pathogenesis, role of stress in this disease is yet to be grounded. There is emerging body of evidence on cortisol and PCOS, although it is currently equivocal.Methods Medline, Embase, Pubmed, Science Direct, Google Scholar, and Scopus were searched from March 1985 to March 2020 using MeSH terms. After dual quality assessments and data abstraction, the final articles were included for meta-analysis.Results Forty-one studies qualified for the analysis. Pooled meta-analysis showed that the level of cortisol was significantly higher in PCOS when compared to healthy controls (standard mean difference [SMD] = 0.83, 95% confidence interval [CI] = 0.42–1.23) with highly significant heterogeneity (I2 = 94%). Subgroup analysis done based on type of sample stated high effect size for blood cortisol levels (SMD = 0.9, 95%CI = 0.32; 1.51) compared to overall effect.Conclusions This systematic review and meta-analysis on cortisol and PCOS have helped in generating evidence regarding the role of cortisol in the pathogenesis of PCOS and the use of cortisol estimation as a potential stress marker in PCOS.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cortisol and polycystic ovarian syndrome – a systematic search and meta-analysis of case–control studies
- Date Crossref
- 05/04/2021
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sri Ramachandra Institute of Higher Education and Research pays non établi dans la noticeUniversité ou école supérieure
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Central Council for Research in Yoga & Naturopathy pays non établi dans la noticeStructure de recherche
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Narayan Medical College and Hospital Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
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Sri Ramachandra Medical College and Research Institute Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
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Government Yoga and Naturopathy Medical College and Hospital Biochemistry and Physiology pays non établi dans la noticeUniversité ou école supérieure
Sri Ramachandra Institute of Higher Education and Research, Central Council for Research in Yoga & Naturopathy et Department of Physiology — Narayan Medical College and Hospital, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.