Unusual pattern of recurrence and atypical visceral metastases in extremity soft tissue sarcoma: a case report

Le résumé fourni par la source

Abstract: Soft-tissue sarcomas (STS) are a rare group of tumors, commonly arising in the extremities. For extremity STS, the main treatment strategy is limb sparing surgery followed by neoadjuvant radiotherapy. Patterns of disease relapse after multimodal treatment have been analyzed in the past decades, being the lung the first recurrence site. Non-pulmonary metastases are uncommon and are associated with worse prognosis. Local recurrences are less frequent and usually develop after a longer period of time. Local control depends on tumor grade and size, surgical margins and adjuvant radiotherapy. Here, we describe the case of an extremity STS fibrosarcoma in a 30-year-old male that in the course of the disease developed multiple marginal recurrences followed by gastric, lung and soft-tissue metastases. All local recurrences where identified by the patient himself and confirmed by magnetic resonance imaging (MRI). Limb marginal recurrences were treated with a multidisciplinary approach consisting of radical surgery and radiotherapy. Metastatic lesions were initially resected and adjuvant chemotherapy was considered after the last distant failure. STS can have an unpredictable pattern of recurrence, therefore follow-up protocols should be tailored to individual risk. Multimodal management for primary site is the key to achieve higher local control rates, and it should also be considered as an approach for secondary sites in selected patients.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.