Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe
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Le résumé fourni par la source
BACKGROUND: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. METHODS: This was a prospective European observational study (the COVIP study) in ICU patients aged 70 years and older admitted with COVID-19 disease from March to December 2020 to 159 ICUs in 14 European countries. An electronic database was used to register a number of parameters including: SOFA score, Clinical Frailty Scale, co-morbidities, usual ICU procedures and survival at 90 days. The study was registered at ClinicalTrials.gov (NCT04321265). RESULTS: ratio at admission was higher during surge 1, and more patients received invasive mechanical ventilation (78% versus 68%, p < 0.0001). During the first 15 days of treatment, survival was similar during the first and the second surge. Survival was lower in the second surge after day 15 and differed after 30 days (57% vs 50%) as well as after 90 days (51% vs 40%). CONCLUSION: An unexpected, but significant, decrease in 30-day and 90-day survival was observed during the second surge in our cohort of elderly ICU patients. The reason for this is unclear. Our main concern is whether the widespread changes in practice and treatment of COVID-19 between the two surges have contributed to this increased mortality in elderly patients. Further studies are urgently warranted to provide more evidence for current practice in elderly patients. TRIAL REGISTRATION NUMBER: NCT04321265 , registered March 19th, 2020.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe
- Date Crossref
- 23/09/2021
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Heinrich Heine University Düsseldorf pays non établi dans la noticeUniversité ou école supérieure
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Aarhus University Hospital Department of Intensive Care pays non établi dans la noticeÉtablissement de santé
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Paracelsus Medical University Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Universitat Autònoma de Barcelona pays non établi dans la noticeUniversité ou école supérieure
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Centro de Investigación Biomédica en Red de Enfermedades Respiratorias pays non établi dans la noticeStructure de recherche
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Corporació Sanitària Parc Taulí pays non établi dans la noticeInstitution
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University Hospital of Geneva pays non établi dans la noticeÉtablissement de santé
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University of Bern Department of Intensive Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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University Hospital of Bern pays non établi dans la noticeÉtablissement de santé
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Hebrew University of Jerusalem pays non établi dans la noticeUniversité ou école supérieure
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Hadassah Medical Center Department of Medical Intensive Care pays non établi dans la noticeÉtablissement de santé
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Jagiellonian University Center for Intensive Care and Perioperative Medicine pays non établi dans la noticeUniversité ou école supérieure
Heinrich Heine University Düsseldorf, Department of Intensive Care — Aarhus University Hospital et Department of Cardiology — Paracelsus Medical University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.