Tranexamic Acid and Bleeding Parameters Among High Tibial Osteotomy Patients: A Systematic Review and Meta-analysis

Le résumé fourni par la source

Objective: To clarify and elucidate the real correlation between tranexamic acid administration and post-operative bleeding parameters in high tibial osteotomy (HTO) patients. Material and Methods: Articles published in PubMed, Embase, and Cochrane Library were searched and included in our analysis under the eligibility criteria. Information related to bleeding parameters among HTO patients treated with tranexamic acid and placebo was collected and analyzed using random or fixed-effect models. Results: A total of five papers were included in our study. Our pooled calculations found that tranexamic acid was associated with reduced bleeding parameters in HTO patients including drainage volume on the first day (mean diff=1.47 [95% CI=0.33-2.65], p=0.0120), hemoglobin decline on the second day (mean diff=0.79 [95% CI=0.59-1.00], p=0.0000), and total blood loss (mean diff=2.25 [95% CI=0.59-3.91], p=0.0080) compared to control group. However, we failed to elucidate the correlation between tranexamic acid administration and hemoglobin decline on the first day among patients with HTO. Conclusion: Tranexamic acid is associated with reduced drainage volume on the first day, hemoglobin decline on the second day, and total blood loss among HTO patients.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.