The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study
Rattachement africain : de, no, dk, at, es, ch, il, pl, Libye, be, gr, ie, pt, it, gb, fr, nl, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into intensive care, and decisions regarding treatment limitations. Our study sought to determine the interaction of frailty and age in elderly COVID-19 ICU patients. METHODS: A prospective multicentre study of COVID-19 patients ≥ 70 years admitted to intensive care in 138 ICUs from 28 countries was conducted. The primary endpoint was 30-day mortality. Frailty was assessed using the clinical frailty scale. Additionally, comorbidities, management strategies and treatment limitations were recorded. RESULTS: The study included 1346 patients (28% female) with a median age of 75 years (IQR 72-78, range 70-96), 16.3% were older than 80 years, and 21% of the patients were frail. The overall survival at 30 days was 59% (95% CI 56-62), with 66% (63-69) in fit, 53% (47-61) in vulnerable and 41% (35-47) in frail patients (p < 0.001). In frail patients, there was no difference in 30-day survival between different age categories. Frailty was linked to an increased use of treatment limitations and less use of mechanical ventilation. In a model controlling for age, disease severity, sex, treatment limitations and comorbidities, frailty was independently associated with lower survival. CONCLUSION: Frailty provides relevant prognostic information in elderly COVID-19 patients in addition to age and comorbidities. Trial registration Clinicaltrials.gov: NCT04321265 , registered 19 March 2020.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study
- Date Crossref
- 19/04/2021
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Heinrich Heine University Düsseldorf pays non établi dans la noticeUniversité ou école supérieure
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Haukeland University Hospital Department of Anaesthesia and Intensive Care pays non établi dans la noticeÉtablissement de santé
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University of Bergen Department of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Aarhus University Hospital Department of Intensive Care pays non établi dans la noticeÉtablissement de santé
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Paracelsus Medical University Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Universitat Autònoma de Barcelona pays non établi dans la noticeUniversité ou école supérieure
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Centro de Investigación Biomédica en Red de Enfermedades Respiratorias pays non établi dans la noticeStructure de recherche
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Corporació Sanitària Parc Taulí pays non établi dans la noticeInstitution
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University Hospital of Geneva pays non établi dans la noticeÉtablissement de santé
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University of Bern Department of Intensive Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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University Hospital of Bern pays non établi dans la noticeÉtablissement de santé
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Hadassah Medical Center pays non établi dans la noticeÉtablissement de santé
Heinrich Heine University Düsseldorf, Department of Anaesthesia and Intensive Care — Haukeland University Hospital et Department of Clinical Medicine — University of Bergen, avec 9 autres affiliations. Pays d’affiliation : Libye.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.