Self-Diffusion of Fullerene С60 Derivatives in Aqueous Solutions and Suspensions of Erythrocytes According to Pulsed Field Gradient NMR Data

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Abstract Determination of the mechanism of substance penetration in biological cells is one of the fundamental problems of metabolism. Interest in the water-soluble derivatives of fullerene C60 is dictated by their high biological activity (targeted drug delivery, antiviral and antibacterial activity, etc.). Erythrocytes were chosen as a model target. The parameters of molecular diffusion of the water-soluble derivatives of fullerene C60 (pentasubstituted derivative with attached mercaptopropionic acid residues and pentasubstituted derivative with attached proline residues) in aqueous solutions and erythrocyte suspension were obtained. In erythrocyte suspension, the fullerene C60 derivatives exist in the form of isolated and associated molecules in the aqueous phase or are bound to the cell membrane. The relative parts and lifetimes of the molecules of water-soluble fullerene derivatives in erythrocytes were determined.

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