Fluorine‐18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

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18F‐labeled aldehydes can be utilized for oxime coupling with chemically sensitive proteins, such as coagulation factor VII (FVII), if they are sufficiently reactive and can react in an aqueous solvent. New 18F‐labeled nonvolatile aldehyde prosthetic groups derived from [18F]F‐Py‐TFP and spirocyclic iodonium (III)ylide precursors for late stage 18F‐labeling were developed. These precursors were characterized, 18F‐labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino‐oxy modified inhibited factor VII (FVIIai‐ONH2) in low concentration to prove the applicability of the proposed method.

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