Challenges in the development of accurate normative neuropsychological test data for older adults: Findings from the HELIAD Study
Rattachement africain : gr, cy, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background Normative data collected from older adult cohorts may be tainted by the inadvertent inclusion of undiagnosed individuals at the very early stage of a dementia process or Mild Cognitive Impairment (MCI). To avoid this pitfall, we developed normative data from an older adult group who remained cognitively intact at follow‐up examination. The present work addresses the challenge and the absence of appropriate normative data for a range of neuropsychological tests in older adults in Greece. Method 1031 community dwelling participants (age≥65) underwent neurological and neuropsychological assessment on two occasions with a mean interval of 2.8 years (range:1.2‐5.2; SD:0.8) for the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). A value of 0 or 0.5 for the Clinical Dementia Rating (CDR) and a threshold value of ≥ 26 on the Mini Mental State Examination (MMSE) were used as clinical diagnostic criteria to determine the cognitive status of the participants. Based on these criteria, 750 individuals were cognitively intact in both evaluations and their data were used for norms development. Participants received a comprehensive neuropsychological assessment encompassing five cognitive domains: memory, language, attention/speed, executive and visual‐spatial functioning. Multiple linear regression models were performed, with age at baseline (years), education (years) and sex as the demographic predictors for regression‐based normative formulae, and raw test scores as the dependent variables. The effects of age, education and sex were investigated for each test and subtest separately. Discrete norms were also derived, stratified by four age strata (64‐69, 70‐74, 75‐79, 80‐89) and by three education strata (0, 1‐9, 10+). Result Regression analyses revealed that education was associated with all test scores, whereas age was an important predictor of all but a few visuoperceptual, executive functioning and memory variables. Women outperformed men on verbal memory, attention/information processing speed and subtests of executive functioning. Men, however, outperformed women on visual memory recall and visuospatial perception. Conclusion The current study provides sound normative data for widely‐used neuropsychological tests among older adults, untainted by potential early and undiagnosed cognitive impairment. We report both discrete and regression‐based norms for use in clinical settings to identify cognitive decline in older adults.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Challenges in the development of accurate normative neuropsychological test data for older adults: Findings from the HELIAD Study
- Date Crossref
- 01/12/2020
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Aristotle University of Thessaloniki pays non établi dans la noticeUniversité ou école supérieure
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Greek Association of Alzheimer's Disease and Related Disorders pays non établi dans la noticeOrganisation à but non lucratif
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National and Kapodistrian University of Athens pays non établi dans la noticeUniversité ou école supérieure
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Harokopio University of Athens pays non établi dans la noticeUniversité ou école supérieure
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University of Cyprus pays non établi dans la noticeUniversité ou école supérieure
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University of Thessaly pays non établi dans la noticeUniversité ou école supérieure
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Columbia University pays non établi dans la noticeUniversité ou école supérieure
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Athens Alzheimer Association Athens Greece pays non établi dans la noticeOrganisation à but non lucratif
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Harokopion University of Athens Athens Greece pays non établi dans la noticeUniversité ou école supérieure
Aristotle University of Thessaloniki, Greek Association of Alzheimer's Disease and Related Disorders et National and Kapodistrian University of Athens, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.