Abstract PO-156: Emerging demographic changes of first eighteen (18) most common cancers among West Africans in Zaria Nigeria (1972 – 2019)

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Abstract The African continent is facing enormous challenges from cancer crisis, and the lack of reliable population database on cancer incidence and mortality hinders high quality decision on prevention and management modalities. The objective of this study is to analyze the trend of malignant tumors in a population of rural Africans attending Ahmadu Bello University Teaching (ABUTH) Hospital Zaria, Nigeria with particular emphasis on the first eighteen (18) frequently diagnosed cancers over a period of 46 consecutive years (1972 - 2019) excluding the year 1988. Histologically diagnosed cancers from the population-based cancer registry of the ABUTH Zaria were included in this study. There were 19, 884 histologically diagnosed cancers over 46 years in ABUTH Zaria with the following in descending order: Cervical cancer 2,335 (12%, [squamous cell carcinoma = 1, 809; others = 529]), Breast cancer 1,982 (10% [invasive ductal carcinoma = 1,589; others = 393]), Lymphoma 1,927 (10% [non–Hodgkin’s lymphoma = 1,335; Hodgkin’s lymphoma = 492]), Sarcomas 1,177 (6% [Kaposi sarcoma = 296; Rhabdomyosarcoma = 172; Osteosarcoma = 166; Dermatofibrosarcoma = 102; Fibrosarcoma = 83; others = 358]), Prostate cancer 1,073 (5%), Colorectal cancer 816 (4% [other adenocarcinomas = 666, mucinous adenocarcinoma = 93; signet ring cell adenocarcinoma =14, others = 43]), Non- melanoma skin cancer 717 (4%), Eye/ Orbit cancer 537 (3% [retinoblastoma = 302; squamous cell eye cancer = 153; others = 82]), Bladder cancer 515 (3%), Liver cancer 481 (2% [primary liver cell carcinoma = 399; others = 79]), Salivary gland cancer 398 (2%), Melanoma 394 (2%), Ovarian cancer 278 (1%), Nasopharyngeal cancer 235 (1%), Kidney cancer 201 (1% [nephroblastoma = 113; renal cell carcinoma = 77; others = 11]), Esophageal cancer 145 (1%), Thyroid cancer 122 (1%), Pancreatic cancer 60 (0.29%) and Others 7,053 (33%). This total, exclude referred cancer cases to oncology department of ABUTH from other hospitals across the country which makes up 60% of cancer cases treated in institution and a handful of clinically diagnosed cases. The results show unusual change in trend with: 2 fold increase for cervical cancer, 6 fold increase for Breast cancer, 8 fold increase for Prostate cancer, 3 fold increase for colorectal cancer; 6 fold increase for Pancreatic cancer, 13 fold increase for Nasopharyngeal cancer and 16 fold increase for Oesophageal cancer when comparing incidence of cancer from 2011-2019 with 1972-1980. However, the results show 12 fold decrease for Liver cancer and 3 fold decrease each for Lymphoma and Non-melanoma skin cancer when comparing cancer cases from 2011-2019 with 1972 - 1980. Understanding the phenomenon behind the rapid change in trend of different cancer types in sub Saharan Africa may contribute to addressing cancer challenges and better policy decision on cancer in the continent. Citation Format: Faruk Mohammed, Abdulmumini Hassan Rafindadi, Sani Ibrahim, Yawale Iliyasu, Sirajo Mohammed Aminu, Ahmed Adamu, Adamu Abdullahi, Aishatu Maude Suleiman, Abdullahi Mohammed, John Idoko, Abdulkadir Lawal Rafindadi, Danladi Amodu Ameh, Bello Kumo, Ahmad Bello, Abdullahi Jubril Randawa, Usman Mohammed Aminu, Muhammad Manko, Tajudeen Olasinde, Mohammed Dauda Maigatari, Ahmed Mai, LMD Yusuf, Abdullahi Alfa Mohammed, Yahaya Ukwenya, Oguntayo Olanrewaju Adekunle, Maitama Yusuf Hussaini. Emerging demographic changes of first eighteen (18) most common cancers among West Africans in Zaria Nigeria (1972 – 2019) [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-156.

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