Experience of a Portuguese radiation therapy department in the treatment of synchronous and metachronous head, neck, and oesophageal cancers

Résumé fourni par la source

Abstract Background: Multiple primary cancers in patients with head and neck squamous cell carcinoma (HNSCC) and oesophageal squamous cell carcinoma (ESCC) share common features. Their treatment approach can be a challenge. This retrospective study aims to estimate the cumulative incidence and to describe the outcome of patients with multiple primary cancers, treated in a Tertiary Centre in Portugal. Methods: The study includes patients with HNSCC, ESCC, and multiple tumours (synchronous or metachronous), treated with curative intent in a Centre, between 2004 and 2019. The analysis is focused on the clinical baseline characteristics, the treatment approach, and the outcomes. Patients with distant metastasis at tumour diagnosis were excluded. Results: Of a total of 820 cases, 31 had multiple tumours. In 15.8 years, the cumulative incidence of multiple tumours was 6.45%. Twenty-seven patients were treated with curative intent (n = 7 synchronous, n = 20 metachronous). The most frequent HNSCC cancers in synchronous tumours were oropharynx and hypopharynx tumours (n = 4); oral cavity was the most frequent HNSCC cancer (n = 12) in metachronous tumours. The primary treatment included surgery, adjuvant or definitive radiation therapy or chemoradiation. With a median follow-up time of 73 months, the median overall survival was 51.8 months for synchronous and 102 months for metachronous tumours. Conclusions: Multiple tumours of HNSCC and ESCC are uncommon. In the small group of Portuguese patients analysed, there is a potential pattern of occurrence and treatment outcome. Due to the limited number of patients this study has included, the authors have considered that additional prospective studies with large samples are needed.

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