Risk of Cancer in Middle-aged Patients With Gout: A Nationwide Population-based Study in Korea

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OBJECTIVE: Gout is reportedly associated with a higher incidence of cancer. However, patients with gout tend to have several cancer-related factors including obesity, smoking, and alcohol consumption; thus, the precise association between gout and cancer risk remains unclear. We aimed to investigate the risk of cancer in Korean patients with gout. METHODS: Based on the Korea Health Insurance Service database, the subjects comprised patients aged 41-55 years with gout newly diagnosed between 2003 and 2007. We used a multivariable-adjusted Cox proportional hazards model in gout patients and a 1:2 ratio for the matched controls by age, sex, and index year. RESULTS: We compared 4176 patients with gout with 8352 controls. The mean age and follow-up duration were 48.8 years and 10.1 years in both groups. Overall cancer risk was significantly different between gout patients and controls (HR 1.224, 95% CI 1.073-1.398). The all-cause mortality (HR 1.457, 95% CI 1.149-1.847) and cancer mortality (HR 1.470, 95% CI 1.020-2.136) were higher in patients with gout. In the subgroup analysis, the cancer risks of the stomach (HR 1.710, 95% CI 1.221-2.395), head and neck (HR 1.850, 95% CI 1.071-3.196), and hematologic or lymphoid organ (HR 2.849, 95% CI 1.035-7.844) were higher in patients with gout. CONCLUSION: Patients aged 41-55 years with gout have a higher risk of cancer and all-cause and cancer mortality compared with the general population. Therefore, special attention should be paid to higher cancer risk and mortality in these patients who are diagnosed in middle age.

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