Feasibility and acceptability of implementing early infant diagnosis of HIV in Papua New Guinea at the point of care: a qualitative exploration of health worker and key informant perspectives
Rattachement africain : au, pg, be, Kenya. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
INTRODUCTION: Early infant diagnosis (EID) of HIV and timely initiation of antiretroviral therapy can significantly reduce morbidity and mortality among HIV-positive infants. Access to EID is limited in many low-income and middle-income settings, particularly those in which standard care involves dried blood spots (DBS) sent to centralised laboratories, such as in Papua New Guinea (PNG). We conducted a qualitative exploration of the feasibility and acceptability of implementing a point-of-care (POC) EID test (Xpert HIV-1 Qualitative assay) among health workers and key stakeholders working within the prevention of mother-to-child transmission of HIV (PMTCT) programme in PNG. METHODS: This qualitative substudy was conducted as part of a pragmatic trial to investigate the effectiveness of the Xpert HIV-1 Qualitative test for EID in PNG and Myanmar. Semistructured interviews were undertaken with 5 health workers and 13 key informants to explore current services, experiences of EID testing, perspectives on the Xpert test and the feasibility of integrating and scaling up POC EID in PNG. Coding was undertaken using inductive and deductive approaches, drawing on existing acceptability and feasibility frameworks. RESULTS: Health workers and key informants (N=18) felt EID at POC was feasible to implement and beneficial to HIV-exposed infants and their families, staff and the PMTCT programme more broadly. All study participants highlighted starting HIV-positive infants on treatment immediately as the main advantage of POC EID compared with standard care DBS testing. Health workers identified insufficient resources to follow up infants and caregivers and space constraints in hospitals as barriers to implementation. Participants emphasised the importance of adequate human resources, ongoing training and support, appropriate coordination and a sustainable supply of consumables to ensure effective scale-up of the test throughout PNG. CONCLUSIONS: Implementation of POC EID in a low HIV prevalence setting such as PNG is likely to be both feasible and beneficial with careful planning and adequate resources. TRIAL REGISTRATION NUMBER: 12616000734460.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Feasibility and acceptability of implementing early infant diagnosis of HIV in Papua New Guinea at the point of care: a qualitative exploration of health worker and key informant perspectives
- Date Crossref
- 01/11/2020
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Burnet Institute pays non établi dans la noticeOrganisation à but non lucratif
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Monash University pays non établi dans la noticeUniversité ou école supérieure
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Papua New Guinea Institute of Medical Research Sexual and Reproductive Health Unit pays non établi dans la noticeStructure de recherche
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UNSW Sydney pays non établi dans la noticeUniversité ou école supérieure
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Kirby Institute pays non établi dans la noticeStructure de recherche
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Ghent University Department of Public Health and Primary Care pays non établi dans la noticeUniversité ou école supérieure
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Aga Khan University Nairobi Department of Population Health Aga Khan University Nairobi, Kenya (code pays fourni par la source)Université ou école supérieure
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School of Public Health and Preventive Medicine Department of Epidemiology and Preventive Medicine pays non établi dans la noticeUniversité ou école supérieure
Burnet Institute, Monash University et Sexual and Reproductive Health Unit — Papua New Guinea Institute of Medical Research, avec 5 autres affiliations. Pays d’affiliation : Kenya.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.