How many patients recover from acute kidney injury after pulmonary embolism?

Résumé fourni par la source

Background: Acute kidney injury (AKI) is a frequent complication of acute medical and surgical diseases. Recently, we found AKI to occur in one in three patients with pulmonary embolism (PE), being an increased risk of death and bleeding. Evolution of renal function in patients with AKI and PE is unknown. Aim: To report the proportion of patients with AKI who recover a normal renal function, after PE. Methods: In a post-hoc analysis of patients with symptomatic PE, prospectively included from September 2013 to October 2018, in whom AKI (KDIGO guidelines) was diagnosed at the time of PE, and with at least one Serum Creatinine value measurement through the follow-up. The primary outcome was the proportion of patients who recover from AKI, defined as disappearance of AKI criteria during follow-up (any creatinine assessment during the follow-up). Secondary outcomes were timing of recovery, and characteristics associated with AKI recovery during follow-up, in univariable and multivariable analysis. Results: Among the 270 patients with acute PE, 41 (15.19%, 95%CI [11.12-20.03]) had AKI at baseline. Thirty patients (73%, 95%CI [57-86]) recovered, 24 at day 7. Only presence of cancer was associated with no recovery, in univariate analysis. Conclusion: In PE patients with AKI, renal recovery is frequent and rapid. However, about a quarter of patients did not fully recover, at least 90 days after PE.

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