Longitudinal plasma inflammatory proteome profiling during pregnancy in the Born into Life study
Rattachement africain : se. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The maternal immune system is going through considerable changes during pregnancy. However, little is known about the determinants of the inflammatory proteome and its relation to pregnancy stages. Our aim was to investigate the plasma inflammatory proteome before, during and after pregnancy. In addition we wanted to test whether maternal and child outcomes were associated with the proteome. A cohort of 94 healthy women, enrolled in a longitudinal study with assessments at up to five time points around pregnancy, ninety-two inflammatory proteins were analysed in plasma with a multiplex Proximity Extension Assay. First, principal components analysis were applied and thereafter regression modelling while correcting for multiple testing. We found profound shifts in the overall inflammatory proteome associated with pregnancy stage after multiple testing (p < .001). Moreover, maternal body mass index (BMI) was associated with inflammatory proteome primarily driven by VEGFA, CCL3 and CSF-1 (p < .05). The levels of most inflammatory proteins changed substantially during pregnancy and some of these were related to biological processes such as regulation of immune response. Maternal BMI was significantly associated with higher levels of three inflammation proteins calling for more research in the interplay between pregnancy, inflammation and BMI.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Longitudinal plasma inflammatory proteome profiling during pregnancy in the Born into Life study
- Date Crossref
- 20/10/2020
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Karolinska Institutet Department of Medical Epidemiology and Biostatistics pays non établi dans la noticeUniversité ou école supérieure
-
Danderyds sjukhus pays non établi dans la noticeÉtablissement de santé
-
Uppsala University Department of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Science for Life Laboratory pays non établi dans la noticeStructure de recherche
-
Karolinska University Hospital Astrid Lindgren Children's Hospital pays non établi dans la noticeÉtablissement de santé
-
Department of Clinical Sciences pays non établi dans la noticeÉtablissement de santé
-
Institute of Environmental Medicine pays non établi dans la noticeStructure de recherche
Department of Medical Epidemiology and Biostatistics — Karolinska Institutet, Danderyds sjukhus et Department of Medical Sciences — Uppsala University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.