Long-term Oncologic Impact of Positive Anterior and Posterior Surgical Margins After Radical Prostatectomy
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Le résumé fourni par la source
OBJECTIVE: The objective of this study was to evaluate the impact of the anterior/posterior status of positive surgical margin (PSM) on long-term outcomes after radical prostatectomy for prostate cancer. PATIENTS AND METHODS: We included 391 consecutive PSM patients after radical prostatectomy between 1993 and 2007 excluding cases with multiple location PSM or lack of anterior/posterior status data. The oncologic impact of anterior-PSM and posterior-PSM were examined by Kaplan-Meier analysis and the Cox proportional hazards model. RESULTS: There were 115 cases (29.4%) with apex-PSM, 257 cases (65.7%) with peripheral PSM, and 19 cases (4.9%) with bladder neck PSM. Among the 257 peripheral PSM cases, 58 cases (22.6%) were with anterior-PSM, 174 cases (67.7%) were with posterior-PSM, and 25 cases (9.7%) were with both anterior and posterior PSM. Over a median follow-up of 12.6 years, patients with anterior-PSM, especially those with low to intermediate Gleason score (≤7), showed a biochemical recurrence (BCR) prognosis similar to those with apex-PSM. In contrast, patients with posterior-PSM showed significantly higher BCR risk on both univariate and multivariate analyses when compared with those with apex-PSM. No impact on metastasis-free survival or overall survival was observed. CONCLUSIONS: In our study, we found that prostate cancer patients with anterior-PSM showed a more favorable BCR prognosis similar to those with apex-PSM when comparing to patients with posterior-PSM. Our study results may help physicians to choose different treatment options for patients diagnosed with different PSM status including considering further adjuvant treatment for patients with posterior-PSM.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Long-term Oncologic Impact of Positive Anterior and Posterior Surgical Margins After Radical Prostatectomy
- Date Crossref
- 29/09/2020
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Massachusetts General Hospital Pathology pays non établi dans la noticeÉtablissement de santé
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University Hospital of Geneva pays non établi dans la noticeÉtablissement de santé
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Peking University Department of Pathology and Urology pays non établi dans la noticeUniversité ou école supérieure
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Peking University Third Hospital pays non établi dans la noticeÉtablissement de santé
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Beth Israel Deaconess Medical Center Division of Urologic Surgery pays non établi dans la noticeÉtablissement de santé
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Urology pays non établi dans la noticeInstitution
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Geneva University Hospital Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
Pathology — Massachusetts General Hospital, University Hospital of Geneva et Department of Pathology and Urology — Peking University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.