Antibody responses after COVID-19 infection in patients who are mildly symptomatic or asymptomatic in Bangladesh
Rattachement africain : bd, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: Studies on serological responses following coronavirus disease-2019 (COVID-19) have been published primarily in individuals who are moderately or severely symptomatic, but there are few data from individuals who are mildly symptomatic or asymptomatic. METHODS: We measured IgG, IgM, and IgA to the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by using enzyme-linked immunosorbent assay in mildly symptomatic (n = 108) and asymptomatic (n = 63) on days 1, 7, 14, and 30 following RT-PCR confirmation in Bangladesh and when compared with pre-pandemic samples, including healthy controls (n = 73) and individuals infected with other viruses (n = 79). RESULTS: Mildly symptomatic individuals developed IgM and IgA responses by day 14 in 72% and 83% of individuals, respectively, while 95% of individuals developed IgG response, and rose to 100% by day 30. In contrast, individuals infected with SARS-CoV-2 but who remained asymptomatic developed antibody responses significantly less frequently, with only 20% positive for IgA and 22% positive for IgM by day 14, and 45% positive for IgG by day 30 after infection. CONCLUSIONS: These results confirm immune responses are generated following COVID-19 who develop mildly symptomatic illness. However, those with asymptomatic infection do not respond or have lower antibody levels. These results will impact modeling needed for determining herd immunity generated by natural infection or vaccination.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Antibody responses after COVID-19 infection in patients who are mildly symptomatic or asymptomatic in Bangladesh
- Date Crossref
- 01/12/2020
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Institute of Epidemiology pays non établi dans la noticeOrganisme public
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International Centre for Diarrhoeal Disease Research pays non établi dans la noticeStructure de recherche
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Massachusetts General Hospital Division of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Bangladesh Institute of Development Studies pays non établi dans la noticeStructure de recherche
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Institute for Developing Science & Health initiatives pays non établi dans la noticeOrganisation à but non lucratif
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Infectious Diseases Division pays non établi dans la noticeInstitution
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Departments of Medicine and Pediatrics pays non établi dans la noticeInstitution
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Harvard T.H. Chan School of Public Health Massachusetts General Hospital pays non établi dans la noticeUniversité ou école supérieure
Institute of Epidemiology, International Centre for Diarrhoeal Disease Research et Harvard University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.