Disturbed postprandial lipid metabolism in patients with psoriasis: a preliminary report

Le résumé fourni par la source

Psoriasis is a common immune-mediated skin disease with well-known metabolic influences.Patients with psoriasis may have a predisposition to insulin resistance, and several studies have shown increased rates of diabetes mellitus, hypertension, hyperlipidemia, obesity, and metabolic syndrome.1-4 Chronic inflammatory state in psoriasis may cause increased risk for atherosclerosis, myocardial infarction (MI), and stroke.5,6 A significantly deteriorated profile of lipids, lipoproteins and their oxidized products in patients with psoriasis was observed in previous studies, with higher values of low-density lipoprotein (LDL), triglycerides (TG), and significantly decreased high-density lipoprotein (HDL) levels.7,8 According to many epidemiological and case-control studies, it was demonstrated that non-fasting (postprandial) TG concentration was a clinically significant and independent predictor of the risk of cardiovascular diseases (CVD).9,10 In this preliminary report, it was aimed to investigate postprandial lipid metabolism in patients with psoriasis and controls by using oral fat tolerance test (OFTT).

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.