Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
27Citations signalées, ce qui n’est pas une note de qualité
215Institutions déclarées
32Pays d’affiliation déclarés
Rattachement africain : gb, us, jp, fi, kr, cy, de, sg, es, nl, ca, mx, is, ee, dk, in, hk, cn, tw, fr, lk, gr, se, bd, at, ph, no, Afrique du Sud, mo, sa, au, pk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
ABSTRACT We assembled an ancestrally diverse collection of genome-wide association studies of type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). We identified 277 loci at genome-wide significance ( p <5×10 -8 ), including 237 attaining a more stringent trans-ancestry threshold ( p <5×10 -9 ), which were delineated to 338 distinct association signals. Trans-ancestry meta-regression offered substantial enhancements to fine-mapping, with 58.6% of associations more precisely localised due to population diversity, and 54.4% of signals resolved to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying foundations for functional investigations. Trans-ancestry genetic risk scores enhanced transferability across diverse populations, providing a step towards more effective clinical translation to improve global health.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
- Date Crossref
- 23/09/2020
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Centre for Human GeneticsUniversity of OxfordOxford Centre for Diabetes, Endocrinology and MetabolismUniversity of North Carolina at Chapel HillAmherst CollegeUniversity of Massachusetts AmherstEaling HospitalLondon North West Healthcare NHS TrustEaling Hospital NHS TrustImperial College LondonWake Forest UniversityVanderbilt University Medical CenterTohoku UniversityTohoku University HospitalTohoku Medical Megabank OrganizationUniversity of HelsinkiInstitute for Molecular Medicine FinlandHuman Genome Sciences (United States)Korea National Institute of HealthRIKEN Center for Integrative Medical SciencesBroad InstituteHarvard UniversityMassachusetts General HospitalUniversity of MichiganStatistical ServiceStatistical Research (United States)Seoul National University HospitalWellcome Sanger InstituteHelmholtz MunichAgency for Science, Technology and ResearchNational University of SingaporeNanyang Technological UniversityUniversity of California San DiegoCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas AsociadasCentre for Genomic RegulationNuffield HealthChild Health and Development InstituteIcahn School of Medicine at Mount SinaiNational Center for Global Health and MedicineIo Therapeutics (United States)Erasmus MCThe Lundquist InstituteHarbor–UCLA Medical CenterUCLA Medical CenterPopulation Health Research InstituteLos Angeles Biomedical Research InstituteHamilton Health SciencesMcMaster UniversityNagoya UniversityUniversity of CambridgeMRC Epidemiology UnitUniversity of PennsylvaniaInstituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránSecretaría de Ciencia, Humanidades, Tecnología e InnovaciónNational University Health SystemUniversity of TorontoKyoto UniversityWellcome/MRC Institute of Metabolic SciencedeCODE Genetics (Iceland)University of LiverpoolUniversity of TartuUniversity of CopenhagenNovo Nordisk FoundationBrown UniversityBrigham and Women's HospitalCircadian (United States)University of FreiburgBoston UniversityDeutsches Diabetes-Zentrum e.V.German Center for Diabetes ResearchHeinrich Heine University DüsseldorfKeck Hospital of USCLeiden University Medical CenterChicago Department of Public HealthUniversity of ChicagoUniversity of VirginiaCentre for Cellular and Molecular BiologyChinese University of Hong KongShanghai Jiao Tong UniversityNorthwestern UniversityInstitute of Biomedical Sciences, Academia SinicaCentre National de la Recherche ScientifiqueInstitut Pasteur de Lille(Epi)génomique fonctionnelle métabolique et des dysfonctions dans le diabète de type 2 et des maladies associéesJohns Hopkins UniversityJohns Hopkins MedicineNational Institutes of HealthNational Institute on AgingNational Human Genome Research InstituteUniversity of WashingtonKaiser PermanenteHallym UniversityKyushu UniversityImpactChinese Academy of Medical Sciences & Peking Union Medical CollegeUniversity of Southern DenmarkVejle SygehusSingapore National Eye CenterSingapore Eye Research InstituteMedical Research CouncilNational Taiwan UniversityNational Taiwan University HospitalUniversity of VermontUniversity of KelaniyaHarokopio University of AthensFriedrich-Alexander-Universität Erlangen-NürnbergCharité - Universitätsmedizin BerlinCalifornia Pacific Medical CenterUniversity of GlasgowThe University of Texas Health Science Center at HoustonUniversity of ExeterUppsala UniversityInstituto Nacional de Salud PúblicaCedars-Sinai Medical CenterVanderbilt UniversityUniversity of MinnesotaThe Ohio State University Wexner Medical CenterChinese National Human Genome CenterChinese National Human Genome Center at ShanghaiTri-Service General Hospital Songshan BranchNational Defense Medical CenterNational Yang Ming Chiao Tung UniversityTaipei Veterans General HospitalNational Yang Ming Chiao Tung UniversityJichi Medical UniversityUniversity of Chicago Research BangladeshHeidelberg UniversityUniversity Hospital HeidelbergUniversity Medical Centre MannheimSteno Diabetes CentersFrederiksberg HospitalCenter for Clinical Research and PreventionAalborg UniversityThe University of TokyoCity of HopeThe University of OsakaGenome Institute of SingaporeSungkyunkwan UniversityEhime UniversityInnsbruck Medical UniversityUniversität InnsbruckUniversity of Eastern FinlandKuopio University HospitalUniversity of Colorado AnschutzUniversity of Colorado DenverYonsei UniversitySamsung Medical CenterUniversity of San CarlosPeking UniversityJames S. McDonnell FoundationWashington University in St. LouisUniversity of BergenNational and Kapodistrian University of AthensGerman Centre for Cardiovascular ResearchTechnical University of MunichUniversity of EdinburghHasso Plattner InstituteNew York Medical CollegeData Tecnica International (United States)Kelly Services (United States)Queen Mary University of LondonWilliam Harvey Research InstituteNational Institute of Genomic MedicineUniversity of PittsburghUniversity of KwaZulu-NatalInstitute of Genomics and Integrative BiologyAcademy of Scientific and Innovative ResearchFred Hutch Cancer CenterDuke-NUS Medical SchoolZimmer Biomet (Germany)Ludwig-Maximilians-Universität MünchenNational Cerebral and Cardiovascular CenterReykjavík UniversityMacau University of Science and TechnologyChina Medical UniversityChina Medical University HospitalUniversität für Weiterbildung KremsKing Abdulaziz UniversityFinnish Institute for Health and WelfareEscuela Nacional de SanidadCentro Medico Nacional Siglo XXIHospital de EspecialidadesPenn Presbyterian Medical CenterSouthern California Eye InstituteAarhus UniversityDanish Diabetes AcademyKing Edward Memorial Hospital Research CentreKurume University Medical CenterThe University of QueenslandUPMC Hillman Cancer CenterUniversity of California, IrvineBeth Israel Deaconess Medical CenterScience for Life LaboratoryStanford UniversityKaiser Permanente Washington Health Research InstituteBeijing Tongren HospitalCapital Medical UniversityDuke UniversityTUM KlinikumKurume UniversityMcGill UniversityGenomics (United Kingdom)Jackson Memorial HospitalUniversity of Mississippi Medical CenterTaichung Veterans General HospitalLund UniversityJawaharlal Nehru UniversitySeoul National UniversityUniversity of DundeeImperial College Healthcare NHS TrustCenter for Non-Communicable DiseasesUniversity of the RyukyusChurchill HospitalUniversity of ManchesterArthritis UK
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
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