Estimation of the predictive role of presenting symptoms in establishing the diagnosis of idiophatic intracranial hypertension, course and outcome of the disease

Le résumé fourni par la source

Idiopathic intracranial hypertension (IIH) is a rare disease characterized by increased intracranial pressure (ICP) in the absence of any other detectable cause. Clinical presentation of IIH is variable, with the most frequent finding of papilledema and headache. Other symptoms include transient visual obscurations (TVO), blurred vision, double vision due to sixth nerve palsy, tinnitus, dizziness, nausea, neck pain, disturbed concentration and memory impairment. The diagnostic value of this variety of presenting symptoms and clinical findings has been scarcely investigated. Current diagnostic criteria for IIH are not based on clinical presentation of the disease, and unlike former criteria do not include specific symptoms of raised ICP. Low prevalence of IIH results in insufficient data regarding the course and long-term outcome of the disease.\nObjectives: The main aims of the study are to a) characterize the presenting symptoms and signs of IIH defined according to the existing diagnostic criteria, b) analyze the correlation of presenting symptoms and signs with the results of diagnostic procedures: ICP measurement, presence of papilledema, and neuroimaging markers of raised intracranial pressure c) investigate the correlation of presenting symptoms and signs with the course and disease outcome.\nMethods: This cohort study was conducted in two tertiary centers: Neurology Clinic of the Clinical Center of Serbia and the Danish Headache Center-Rigshospitalet, Glostrup. The study included 286 patients that were consecutively referred by attending neurologist and ophthalmologist for the evaluation of possible IIH from January 2007 to March 2016. The study was conducted in two phases. At first, clinical data were prospectively collected from all study participants in order to evaluate the presenting symptoms and signs of IIH...

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