Antibodies against Phosphorylcholine and Malondialdehyde during the First Two Years of Life
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Le résumé fourni par la source
Abstract Abs against phosphorylcholine (anti-PC) and Abs against malondialdehyde (anti-MDA) may be protective in chronic inflammation, like atherosclerosis and cardiovascular disease. It is not known how they develop early in life. Ab titers were measured using ELISA in healthy women (n = 105; born into life study) and their children. Plasma samples were collected from the mothers before conception and from the children at birth as well as at 1 and 2 y after birth. Extracted Abs were compared using a proteomics de novo sequencing approach. It was observed that children were born with very low levels of IgM anti-PC, whereas IgM anti-MDA was present at birth. Both IgM anti-PC and anti-MDA increased during the first 2 y of life, but IgM anti-PC in contrast to IgM anti-MDA was still significantly lower than in the mothers. IgG anti-PC decreased after 1 y but reached similar levels as mothers’ after 2 y, whereas IgG anti-MDA reached similar levels as mothers’ already after 1 y. Proteomics peptide sequencing analysis indicated large peptide sequence variation without specific clone expression during the early stage of life compared with the adult stage for which specific peptide sequences dominated. IgM anti-PC levels develop much slower than anti-MDA and are still relatively low at 2 y. We hypothesize that anti-PC is developed by a combination of preprogramming and exposure to the external world, in which infectious agents may play a role. For anti-MDA, preprogramming is likely to play a major role and at an earlier stage than for anti-PC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Antibodies against Phosphorylcholine and Malondialdehyde during the First Two Years of Life
- Date Crossref
- 01/10/2020
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Karolinska Institutet Department of Medical Biochemistry and Biophysics pays non établi dans la noticeUniversité ou école supérieure
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Region Stockholm pays non établi dans la noticeOrganisme public
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Karolinska University Hospital Astrid Lindgren Children’s Hospital pays non établi dans la noticeÉtablissement de santé
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Danderyds sjukhus pays non établi dans la noticeÉtablissement de santé
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Glanrhyd Hospital pays non établi dans la noticeÉtablissement de santé
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Institute of Environmental Medicine pays non établi dans la noticeStructure de recherche
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Centre for Occupational and Environmental Medicine pays non établi dans la noticeInstitution
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Department of Clinical Sciences pays non établi dans la noticeÉtablissement de santé
Department of Medical Biochemistry and Biophysics — Karolinska Institutet, Region Stockholm et Astrid Lindgren Children’s Hospital — Karolinska University Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.