Delayed administration method of clomiphene citrate during the ovulatory phase in patients with a prolonged menstrual cycle

Le résumé fourni par la source

For patients with a prolonged menstrual cycle who do not respond to clomiphene citrate, the drug can be administered again at a higher dose during another cycle. Clomiphene citrate should be administrated two to five days after the start of menstruation; however, enhanced ovulation effects may occur as a potential adverse reaction to high-dose clomiphene citrate therapy, which limits its use. Furthermore, the ovulatory-phase timing of administration differs between normal patients and those with a prolonged menstrual cycle. This indicates clomiphene citrate does not directly act on the ovulatory phase. The authors used a delayed administration of clomiphene citrate without increasing its doses in a patient with a prolonged menstrual cycle who did not respond to conventional clomiphene citrate therapy. They achieved three pregnancies and deliveries in the patient using this method.

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