PO-190: Local and systemic abolition of metastatic cancer by alpha particle brachytherapy and immunotherapy

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Material and MethodsAt our institution, Integrated Oncology services include rehabilitation along with Surgical, Medical and Radiation Oncology services.An Observational study was performed in consecutive 46 patients of breast cancer who underwent Rehabilitation interventions in the form of Nutritional assessment, Physiotherapy, Aerobic exercises, Yoga exercises, Relaxation techniques, Breathing exercises, Light weight training and Counselling during their radiotherapy treatment.Physical endurance was measured by six minutes walk test distance (6MWTD) and QOL was assessed by Functional assessment of chronic illness therapy (FACIT -B) Questionnaire before starting interventions and after completion. ResultsAll patients had a significant improvement in 6MWTD (p=0.0001)post rehabilitation interventions.Patients younger than Age ≤ 55 years had significantly more improvement in the 6MWTD post interventions compared to older patients (p=0.003).There was no significant difference in the improvement in 6MWTD in patients undergoing Breast conservation versus mastectomy, conventional fractionated versus hypo-fractionated radiotherapy or Presence or absence of co-morbidities.Patients who had not received chemotherapy, did not show significant difference in 6MWTD pre and post intervention.All patients assessed (n=34) showed a significant improvement in their physical (p=0.026),emotional(p=0.050) and additional well being(p=0.036);while social(P=0.345)and functional(P=0.109)well being did not show significant improvement as assessed by FACIT-B Questionnaire. ConclusionIntegrated Oncology services with Rehabilitation interventions as a part of management of patients with breast cancer has a significant impact on Physical Endurance as well as overall Quality of Life of these patients. PO-189Training teamwork and safe clinical practice using full immersion simulation R.

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