CD8+ tumor‐infiltrating lymphocytes within the primary tumor of patients with synchronous de novo metastatic colorectal carcinoma do not track with survival
Rattachement africain : au. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Objectives Tumor‐infiltrating lymphocytes (TIL), particularly CD8+ TILs in patients with colorectal cancer (CRC), are highly prognostic in the early‐disease stages (I‐II). In metastatic disease (stage IV; mCRC), their influence is less well defined. It has presumably failed to contain tumor cells to the primary site; however, is this evident? We explored the prognostic impact of TILs at the primary site in patients who presented de novo with mCRC. Methods Treatment‐naïve patients (109) with mCRC were assessed for CD8+ TILs and PD‐L1 expression. Microsatellite instability (MSI) was evaluated by IHC for PMS2 and MSH6 proteins and/or by PCR using the Bethesda panel. Results Microsatellite instability‐high tumors had significantly more CD8+ TILs, with no significant survival advantage observed between MSI‐H and microsatellite stable (MSS) tumors (12 vs 19 months, P = 0.304). TIL density for all cases had no impact on OS (low: 20 vs high: 13 months, P = 0.426), while PD‐L1 of 1% or higher was associated with reduced mean survival (9.6 vs 18.9 months; P = 0.038). MSI‐H tumors and associated immune cells had higher PD‐L1 expression than in MSS cases. A positive correlation between PD‐L1 on immune cells and CD8+ve TILs was found. A subset of MSS tumors had relatively high TILs approximating that of MSI‐H tumors. Conclusion In contrast to early‐stage CRC, the immune response in primary tumors of patients with de novo mCRC does not appear to influence survival. A subgroup of MSS tumors was identified with increased TILs/PD‐L1 comparable to MSI‐H tumors, traditionally not be considered for immune checkpoint blockade and perhaps should be.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- CD8<sup>+</sup> tumor‐infiltrating lymphocytes within the primary tumor of patients with synchronous <i>de novo</i> metastatic colorectal carcinoma do not track with survival
- Date Crossref
- 01/01/2020
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
The University of Melbourne Sir Peter MacCallum Department of Oncology pays non établi dans la noticeUniversité ou école supérieure
-
Peter MacCallum Cancer Centre pays non établi dans la noticeÉtablissement de santé
-
St Vincent's Hospital Melbourne Department of Anatomical Pathology pays non établi dans la noticeÉtablissement de santé
-
Footscray Hospital pays non établi dans la noticeÉtablissement de santé
-
Western Health pays non établi dans la noticeÉtablissement de santé
-
The Royal Melbourne Hospital pays non établi dans la noticeOrganisme public
-
Walter and Eliza Hall Institute of Medical Research pays non établi dans la noticeOrganisation à but non lucratif
-
Alfred Health pays non établi dans la noticeÉtablissement de santé
-
Monash University pays non établi dans la noticeUniversité ou école supérieure
-
Sir Peter MacCallum Department of Oncology University of Melbourne Melbourne VIC Australia pays non établi dans la noticeUniversité ou école supérieure
-
St. Vincent's Hospital Melbourne VIC Australia pays non établi dans la noticeÉtablissement de santé
-
Department of Pathology University of Melbourne Melbourne VIC Australia pays non établi dans la noticeUniversité ou école supérieure
Sir Peter MacCallum Department of Oncology — The University of Melbourne, Peter MacCallum Cancer Centre et Department of Anatomical Pathology — St Vincent's Hospital Melbourne, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.