Difficulty in differential diagnosis for renal cancer with microscopic papillary architecture: overlapped pathological features among papillary renal cell carcinoma (RCC), mutinous tubular and spindle cell carcinoma, and unclassified RCC. Lessons from a Japanese multicenter study
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: In our multicenter study evaluating metastatic papillary renal cell carcinoma (PRCC), 29% of tumors diagnosed as PRCC in collaborative institutes were finally diagnosed as other RCCs under central review. In those tumors, mucinous tubular and spindle cell carcinoma (MTSCC) was the leading histology, followed by unclassified RCC (ucRCC). We focused on those patients with MTSCC or ucRCC. METHODS: We reviewed the processes for the pathological diagnoses of nine tumors and reviewed their clinical features. RESULTS: All of the MTSCCs and ucRCCs were positive for AMACR, which is frequently positive in PRCC. Mucin was demonstrated in 80% of the MTSCCs, and its presence is important for their diagnoses. One MTSCC was diagnosed as a mucin-poor variant. The presence of spindle cells with low-grade nuclei was suggestive of MTSCC, but the diagnosis of high-grade MTSCC was difficult. Four tumors were diagnosed as ucRCC by histological and immunohistochemical findings. Three of the four tumors were suspicious of ucRCC in the initial review due to atypical findings as PRCC. Sunitinib and interferon-α were effective for one MTSCC patient who survived for >5 years. Two MTSCC patients who were Memorial Sloan-Kettering Cancer Center poor risk had unfavorable prognoses. One patient with mucin-poor MTSCC had an indolent clinical course. Two of four ucRCC patients showed durable stable disease with targeted agents (TAs) and survived >3 years. CONCLUSION: Some MTSCC metastases progressed very slowly and poor-risk tumors progressed rapidly. Systemic therapies including TAs showed some efficacies. Some patients who have metastatic ucRCC with microscopic papillary architecture can benefit from TAs.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Difficulty in differential diagnosis for renal cancer with microscopic papillary architecture: overlapped pathological features among papillary renal cell carcinoma (RCC), mutinous tubular and spindle cell carcinoma, and unclassified RCC. Lessons from a Japanese multicenter study
- Date Crossref
- 13/07/2020
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Defense Medical College Department of Urology pays non établi dans la noticeUniversité ou école supérieure
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Keio University Department of Diagnostic Pathology pays non établi dans la noticeUniversité ou école supérieure
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Japanese Red Cross Kochi Hospital pays non établi dans la noticeÉtablissement de santé
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Tokyo Women's Medical University Department of Surgical Pathology pays non établi dans la noticeUniversité ou école supérieure
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Kyushu University pays non établi dans la noticeUniversité ou école supérieure
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Sapporo Medical University Department of Urology pays non établi dans la noticeUniversité ou école supérieure
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Tokyo Women's Medical University Adachi Medical Center pays non établi dans la noticeÉtablissement de santé
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University of the Ryukyus Department of Urology pays non établi dans la noticeUniversité ou école supérieure
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Kyoto University pays non établi dans la noticeUniversité ou école supérieure
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Kumamoto University pays non établi dans la noticeUniversité ou école supérieure
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Niigata University pays non établi dans la noticeUniversité ou école supérieure
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Yamaguchi University pays non établi dans la noticeUniversité ou école supérieure
Department of Urology — National Defense Medical College, Department of Diagnostic Pathology — Keio University et Japanese Red Cross Kochi Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.