Accès ouvert déclaré 2020 article

Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019

Angeliki Melidou, Olav Hungnes, Dmitriy I. Pereyaslov, Cornelia Adlhoch, Hannah E. Segaloff, Emmanuel Robesyn, Pasi M Penttinen, Sonja J. Olsen, Monika Redlberger‐Fritz, Therese Popow‐Kraupp, Iris Hasibra, Artan Simaku, Isabelle Thomas, Cyril Barbezange, Amela Dedeić-Ljubović, Nina Rodić-Vukmir, Neli Korsun, Svetla Angenova, Vladimir Draženović, Maria Koliou, Despo Pieridou, Martina Havlíčková, Alexander Nagy, Ramona Trebbien, Mónica Galiano, Catherine Thompson, Niina Ikonen, Anu Haveri, Sylvie Behillil, Vincent Enouf, Martine Valette, Bruno Lina, Mari Gavashelidze, Ann Machablishvili, Georgia Gioula, Maria Exindari, Athanasios Kossyvakis, Andreas F. Mentis, Ralf Dürrwald, Molnár Zsuzsanna, Mónika Rózsa, Arthur Löve, Guðrún Erna, Linda Dunford, Sarah G Fitzpatrick, Maria Rita Castrucci, Simona Puzelli, Altynay Sagymbay, Gaukhar Nussupbayeva, Natālija Zamjatina, Gatis Pakarna, Algirdas Griškevičius, Asta Skrickiene, Guillaume Fournier, Joël Mossong, Jackie Maistre Melillo, Graziella Zahra, Adam Meijer, Ron A. M. Fouchier, Conall McCaughey, Mark G. O’Doherty, Karoline Bragstad, Raquel Guiomar, Pedro Pechirra, Mariana Apostol, Druc Alina, Mihaela Lazăr, Cherciu Carmen Maria, Andrey B. Komissarov, Burtseva Ei, Rory N. Gunson, Samantha J. Shepherd, Elena Tichá, Edita Staroňová, Katarina Prosenc, Nataša Berginc, Francisco Pozo, Inmaculada Casas, Mia Brytting, Åsa Wiman, Ana Rita Gonçalves, Iryna V. Demchyshyna, Alla P. Mironenko, Catherine Moore, Simon L. Cottrell

14Citations signalées, ce qui n’est pas une note de qualité

9Institutions déclarées

7Pays d’affiliation déclarés

Rattachement africain : se, no, dk, be, ba, bg, cy. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

BACKGROUND: The 2018/2019 influenza season in the WHO European Region was dominated by influenza A (H1N1)pdm09 and (H3N2) viruses, with very few influenza B viruses detected. METHODS: Countries in the European Region reported virus characterization data to The European Surveillance System for weeks 40/2018 to 20/2019. These virus antigenic and genetic characterization and haemagglutinin (HA) sequence data were analysed to describe and assess circulating viruses relative to the 2018/2019 vaccine virus components for the northern hemisphere. RESULTS: Thirty countries reported 4776 viruses characterized genetically and 3311 viruses antigenically. All genetically characterized A(H1N1)pdm09 viruses fell in subclade 6B.1A, of which 90% carried the amino acid substitution S183P in the HA gene. Antigenic data indicated that circulating A(H1N1)pdm09 viruses were similar to the 2018/2019 vaccine virus. Genetic data showed that A(H3N2) viruses mostly fell in clade 3C.2a (75%) and 90% of which were subclade 3C.2a1b. A lower proportion fell in clade 3C.3a (23%) and were antigenically distinct from the vaccine virus. All B/Victoria viruses belonged to clade 1A; 30% carried a double amino acid deletion in HA and were genetically and antigenically similar to the vaccine virus component, while 55% carried a triple amino acid deletion or no deletion in HA; these were antigenically distinct from each other and from the vaccine component. All B/Yamagata viruses belonged to clade 3 and were antigenically similar to the virus component in the quadrivalent vaccine for 2018/2019. CONCLUSIONS: A simultaneous circulation of genetically and antigenically diverse A(H3N2) and B/Victoria viruses was observed and represented a challenge to vaccine strain selection.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019
Date Crossref: 01/07/2020
Éditeur: Elsevier BV
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

European Centre for Disease Prevention and Control pays non établi dans la notice
Organisme public
Norwegian Institute of Public Health pays non établi dans la notice
Organisme public
World Health Organization Regional Office for Europe pays non établi dans la notice
Organisme public
Sciensano (Belgium) pays non établi dans la notice
Entreprise
Clinical Center University of Sarajevo pays non établi dans la notice
Établissement de santé
University of Banja Luka Public Health Institute of the Republic of Srpska pays non établi dans la notice
Université ou école supérieure
Public Health Institute of the Republic of Srpska pays non établi dans la notice
Établissement de santé
National Center of Infectious and Parasitic Diseases pays non établi dans la notice
Université ou école supérieure
Ministry of Health Unit for surveillance and control of communicable diseases pays non établi dans la notice
Organisme public
WHO Regional Office for Europe pays non établi dans la notice
Institution
National Influenza Centre for Austria pays non établi dans la notice
Institution
National influenza lab pays non établi dans la notice
Structure de recherche

European Centre for Disease Prevention and Control, Norwegian Institute of Public Health et World Health Organization Regional Office for Europe, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Influenza Virus Research StudiesRespiratory viral infections researchSARS-CoV-2 and COVID-19 Research

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