Anaphylactic shock and brain death induced by doxorubicin hydrochloride liposomes injection

Le résumé fourni par la source

A 32-year-old woman received IV infusion of doxorubicin hydrochloride liposomes injection 20 mg, added into 5% glucose injection 250 ml, for malignant lymphoma. About 1 minute after the initiation of the IV infusion, the patient developed facial flushing and itchy throat. Two minutes later, the patient developed sudden convulsions, loss of consciousness, binocular gaze, trismus, and urinary incontinence. Anaphylactic shock was diagnosed and the drug was discontinued immediately. Treatments such as intravenous injections of adrenaline hydrochloride injection, dexamethasone sodium phosphate injection, and methylprednisolone sodium succinate for injection, oxygen inhalation, intravenous injections of nikethamide injection, lobeline hydrochloride injection, and norepinephrine bitartrate injection, and cardiopulmonary resuscitation were given successively. However, the patient had been in a deep coma without spontaneous breathing and her blood pressure and urination needed to be maintained by drugs. On day 112 of hospitalization, cerebrovascular color ultrasound showed spectrum changes of brain death. On day 253, the patient was discharged at the request of his family members. Key words: Doxorubicin; Liposomes; Anaphylaxis; Shock; Brain death

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.